« Previous
Next »
Seminars in Nuclear Medicine
Volume 31, Issue 4
, Pages 260-277
, October 2001
Evolution of Tc-99m in diagnostic radiopharmaceuticals
References
- . Radioactive isotopes of element 43. Nature. 1937;140:193–194
- . Some chemical properties of element 43. J Chem Phys. 1937;4:712–716
- . Some fission products of uranium. Phys Rev. 1940;57:552
- . The making of missing chemical elements. Nature. 1947;159:8–10
- . Nuclear isomerism of element 43. Phys Rev. 1939;55:808
- . A review of 99mTc generator technology. Int J Appl Radiat Isot. 1982;33:811–819
- . Introduction: Technetium-99m: An historical perspective. Int J Appl Radiat Isot. 1982;33:793–799
- . Technetium-99m Generators: The available options. Int J Appl Radiat Isot. 1982;33:801–809
- . A survey of the production at Brookhaven National Lab of the isotopes for medical research. In: Trans 5th Nuclear Congress, 7th Int. Electronic and Nuclear Symp. Rome. June 1960;p. 225
- Optimization of scanning method using Tc-99m. Nucleonics. 1964;22:50
- . In: Proc. Symp. Radioactive Pharmaceuticals. ORNL 1965. 1965;p. 323–334
- . Properties, uses, radiochemical purity and calibration of Tc-99m. J Nucl Med. 1964;5:871–882
- . Technetium-99m labeled compounds. In: Rayudu GVS editors. Radiotracers for Medical Applications. Boca Raton, FL: CRC Press Inc; 1983;p. 107–185
- . Semi annual report to the Atomic Energy Commission, September 1962. ACRH-18. 1962;76–87
- . Technetium radiopharmaceuticals-Fundamentals, synthesis, structure, and development. Angew Chem Int Ed Engl. 1994;33:2258–2267
- . The development of new radiopharmaceuticals. Eur J Nucl Med. 1990;16:373–385
- . Technetium chemistry and technetium radiopharmaceuticals. In: Lippard SJ editors. Progress in Inorganic Chemistry. New York: John Wiley & Sons, Inc; 1983;p. 75–139
- . Physicochemical concepts in the preparation of technetium radiopharmaceuticals. In: Sampson CB editors. Textbook of Radiopharmacy Theory and Practice. ed 2. Amsterdam: Gordon and Breach Science Publisher; 1994;p. 29–49
- . Development of new radiopharmaceuticals based on N-substitution of iminodiacetic acid. J Nucl Med. 1976;17:633–638
- . A structure-distribution relationship approach leading to the development of 99mTc-mebrofenin. An improved chole-scintigraphic agent. J Nucl Med. 1983;24:423–430
- In: Nunn AD editors. Radiopharmaceuticals Chemistry and Pharmacology. Vol 55:New York: Marcel Dekker, Inc; 1992;
- . In: Technetium and Rhenium in Chemistry and Nuclear Medicine. New York: Verona and Raven Press; 1990;
- . A new complex of Tc-99m for imaging. Radiology. 1971;99:192–196
- . New developments in radiopharmaceuticals for imaging. A review. In: Medical Radionuclide Imaging. Vol I:IAEA; 1980;p. 429–452
- 99mTc-EHDP: A potential radiopharmaceutical for skeletal imaging. J Nucl Med. 1972;13:947–950
- Technetium-99m methylene diphosphonate-A superior agent for skeletal imaging: Comparison with other technetium complexes. J Nucl Med. 1975;16:744–755
- (communications to the editor) . Structural characterization of a 99Tc-diphosphonate complex. Implications for the chemistry of 99mTc-skeletal imaging agents. J Am Chem Soc. 1980;102:2476–2478
- . In: Pharmaceuticals in Medical Imaging. New York: McMillan Publishing Co; 1990;
- Early scintigraphic detection of experimental myocardial infarction in dogs with technetium-99m-glucaric acid. J Nucl Med. 1991;32:263–268
- Crystal structures of coordination compounds. Coord Chem Rev. 1982;44:191–227
- . Analysis of structural data of technetium compounds. Coord Chem Rev. 1987;77:275–324
- . Medical diagnostic imaging with complexes of 99mTc. Coord Chem Rev. 1987;78:253–331
- . In: The Chemistry of Technetium in Medicine. Washington DC: National Academy Press; 1992;
- . Structural survey of technetium complexes. Coord Chem Rev. 1994;135/136:325–397
- . HPLC analysis of Tc-99m iminodiacetate hepatobiliary agents and a question of multiple peaks: Concise communications. J Nucl Med. 1980;21:1180–1184
- Synthesis, characterization and evaluation of 99mTc/99Tc-DIARS and DMPE complexes containing pentadecanoic acid. Nucl Med Biol. 1987;14:545–553
- . Studies on some aspects of the instability of Tc-hexamethyl propylene amine-oxime (Tc-HMPAO). Nucl Med Biol. 1993;20:307–310
- . Labeling of amine ligands with 99mTc in aqueous solutions by ligand exchange. Int J Appl Radiat Isot. 1982;33:891–896
- . Ligand exchange labeling of amine-phenols with 99mTc. Appl Radiat Isot. 1993;44:911–915
- Formulation and evaluation of a two-component lyophilized kit for Tc-Sestamibi: Transchelation preparation of 99mTc-Sestamibi. Nucl Med Biol. 1997;24:697–700
- Preparation of 99mTc-ethylene dicysteine by transchelation using 99mTc-GHA and its evaluation for renal function studies. Nucl Med Commun. 2000;21:977–982
- (Letter to the editor) . Need for new radiopharmaceuticals. J Nucl Med. 1978;19:1182
- . Radiopharmaceuticals: State of the art. Eur J Nucl Med. 1990;17:346–364
- 99mTc-propyleneamine oxime (Tc-99m-PnAO): A potential brain radiopharmaceutical. Eur J Nucl Med. 1984;11:511–516
- Development of a Tc-99m-labelled radiopharmaceutical for cerebral blood flow imaging. Nucl Med Commun. 1985;6:499–506
- Technetium-99m d,l-HM-PAO: A new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion. J Nucl Med. 1987;28:191–202
- Biological evaluation of the Tc-99m complexes of the d and 1 isomer of HMPAO. J Nucl Med. 1992;33:1032
- . Brain radiopharmaceuticals. In: Fritzberg AR editors. Radiopharmaceuticals: Progress and Clinical Perspectives. Vol I:Boca Raton: CRC Press; 1986;p. 21–39
- . Stabilization of technetium-99m, D,L-hexamethylpropyleneamine oxime (99mTc-D,L-HM-PAO) using gentisic acid. Nucl Med Biol. 1989;16:675–680
- Sensitivity of technetium-99m-d,l-HMPAO to radiolysis in aqueous solutions. J Nucl Med. 1991;32:111–115
- (abstr) . Trial of labeling leucocytes with stabilized 99mTc-D,L-HM-PAO by methylene blue. Eur J Nucl Med. 1997;24:1040
- (abstr) Brain retention of Tc-99m-ECD is related to in vivo metabolism. J Nucl Med. 1988;29:747
- . Radiochemical studies of tetradentate amine-phenols. Appl Radiat Isot. 1990;41:557–561
- Technetium complexes of tetradentate chiral amine-phenol ligands. Appl Radiat Isot. 1993;44:1113–1118
- . Technetium-99m complexes of tetradentate amine-phenol ligands: Minor differences in the ligand structure give Tc complexes with significantly different biolocalization. Ind J Nucl Med. 1997;12:204–210
- . Pentadentate chiral aminephenol ligands. Appl Radiat Isot. 1995;46:923–927
- . Technetium complexes of pentadentate amine-phenol ligands. Nucl Med Biol. 1993;20:211–216
- Pentadentate amine phenol complexes of 99mTc. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 3:Verona, Italy: Cortina International; 1990;p. 585–593
- . Evaluation of diamine dithiol-based bifunctional chelate for labeling small molecule with 99mTc. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 3:Verona, Italy: Cortina International; 1990;p. 369–374
- Comparison of Tc-99m aminoalkyl diaminodithiol (DADT) analogs as potential brain blood flow imaging agents. J Nucl Med. 1988;29:73–82
- Comparative evaluation of Tc-99m labeled aminothiols as possible brain perfusion imaging agents. Nucl Med Biol. 1988;15:215–223
- Synthesis and biodistribution of neutral lipid soluble Tc-99m complexes which cross the blood-brain barrier. J Nucl Med. 1984;25:543–549
- . Stereoisomers of neutral oxotechnetium (V) and oxorhenium (V) complexes. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 3:Verona, Italy: Cortina International; 1990;p. 119–124
- (abstr) Comparison of Tc-99m aminoethyl diamidodithiol analogues for brain, blood-flow imaging. J Nucl Med. 1986;27:1050
- (abstr) Pulmonary accumulation of Tc-99m diaminodithiol (DADT) complexes. J Nucl Med. 1987;28:729
- 99mTc-MRP20. A potential brain perfusion agent: In vivo distribution and SPECT studies in non primate animals. J Nucl Med. 1991;32:500–505
- . Quantitative structure distribution relationships (QSDRs) of BATOs. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 3:Verona, Italy: Cortina International; 1990;p. 399–404
- . Technetium compounds for imaging myocardial and cerebral perfusion. Drug News Perspec. 1992;5:174–183
- . A neutral lipophilic technetium-99m complex for regional cerebral blood flow imaging. J Nucl Med. 1990;31:1370–1377
- . Progress and problems in the chemistry of Technetium-99m tracers. Isotopenpraxis. 1988;24:449–454
- Synthesis, characterization and biodistribution studies of a neutral-lipophilic Tc-99m N3S2 chelate. Nucl Med Biol. 1992;19:791–795
- Heart imaging with cationic complexes of technetium. Science. 1981;214:85–86
- Progress in the evaluation and development of Tc-99m radiopharmaceuticals. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium in Chemistry and Nuclear Medicine. Vol 2:New York: Verona and Raven Press; 1986;
- . Cationic Tc-99m complexes as potential myocardial imaging agents. J Nucl Med. 1981;22:897–907
- Myocardial perfusion imaging with 99mTc-DMPE in man. Eur J Nucl Med. 1983;8:371–374
- Biological studies of a new class of technetium complexes: The hexakis(alkylisonitrile)-technetium (I) cations. Nucl Med Biol. 1984;11:225–234
- (abstr) . Myocardial uptake and retention of Tc-99m-hexakis-aliphatic isotnitriles: Evidence for specificity. J Nucl Med. 1986;27:995
- . Cationic radiotracers as myocardial radiopharmaceuticals: Progress and clinical perspectives. In: Fritzberg AR editors. Radiopharmaceuticals: Progress and Clinical Perspectives. Vol I:Boca Raton: CRC; 1986;p. 1–20
- . Studies on the preparation and evaluation of a few technetium radiopharmaceuticals. In: PhD Thesis. Bombay, India: University of Bombay; 1987;
- . Single photon radiopharmaceuticals for imaging myocardial perfusion. In: Nunn AD editors. Radiopharmaceuticals: Chemistry and Pharmacology. New York: Marcell Dekker Inc; 1992;p. 97–139
- Coordination compounds in nuclear medicine. Chem Rev. 1993;93:1137–1156
- . Substitution reactions of 99mTcNCl4: A route to a new class of 99mTc-radiopharmaceuticals. Int J Appl Radiat Isot. 1985;36:133–139
- . Effect of 99mTc-nitrido group on the behaviour of 99mTc radiopharmaceuticals. Int J Appl Radiat Isot. 1985;36:919–923
- Bis(dithiocarbamato)nitrido technetium-99m radiopharmaceuticals: A class of neutral myocardial imaging agents. J Nucl Med. 1994;35:11–12
- Technetium-99m complexes of functionalised diphosphines for myocardial imaging. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 3:Verona Italy: Cortina International; 1990;p. 405–412
- Development of new 99mTc myocardial perfusion imaging agents. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 3:Verona Italy: Cortina International; 1990;p. 365–368
- (abstr) Novel functionalised diphosphine complexes of Tc-99m for myocardial imaging in man. J Nucl Med. 1989;30:818
- Technetium-99m-1,2-bis-(bis[2-ethoxyethyl]phosphino)ethane: Human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent. J Nucl Med. 1993;34:30–38
- (abstr) Phase I study of Tc-99m diphosphine (P53) for myocardial imaging. J Nucl Med. 1991;32:967
- The Noah's ark experiment: Species dependent biodistributions of cationic 99mTc complexes. Nucl Med Biol. 1989;16:191–232
- New oxotechnetium (V) complexes of N,N′-ethylene bis(acetylacetone imine), N,N′-ethylene(salicylideneamine), and O'phenylenebis(salicylidene amine). X-ray structures of the complexes of N, N′-ethylene bis(acetylacetone imine) and N,N′-ethylene(salicylideneamine). Inorg Chem. 1984;23:227–231
- Human biodistribution, dosimetry and clinical use of technetium (III)-99m-Q12. J Nucl Med. 1994;35:1571–1580
- . A definition of substrate specificity in renal transport of organic anions. J Theor Biol. 1965;8:163–192
- Synthesis and biological evaluation of Technetium-99m N,N′-bis(mercaptoacetyl)-2,3-diaminopropionate: A potential replacement for I-131-o-iodohippurate. J Nucl Med. 1982;23:223–229
- . Radio-HPLC: Application to organic and metal chelate chemistry in analytical and chromatographic techniques. In: Wieland DM, Tobes MC, Mangner TJ editor. Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry. New York: Springer Verlag; 1986;p. 183–212
- Synthesis and biological evaluation of Technetium-99m-MAG3 as a hippuran-replacement. J Nucl Med. 1986;27:111–116
- Two-component kit with nonradioactive precursor for the preparation of an enantiomeric form of the kidney function diagnostic agent, Technetium-99m-labeled mercaptoacetyltriglycine. Eur Pat Appl EP. 1991;427:360
- . Technetium-99m-labeled renal function and imaging agent: Synthesis of 99mTc-MAG3 and biodistribution of by-products. Appl Radiat Isot. 1988;39:121–129
- New developments in radiopharmaceuticals in Mallinckrodt. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 3:Verona Italy: Cortina International; 1990;p. 405–412
- Evaluation of 99mTc mercaptoacetyltripeptides in mice and a baboon. Nucl Med Biol. 1992;19:375–388
- . Tc-99m-L,L-ethylene dicysteine as a renal imaging agent. I. Labeling and evaluation in animals. J Nucl Med. 1982;33:551–557
- Isolation of the monoester, monoacid derivatives of 99mTc-ECD and their biodistribution in mice. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 3:Verona, Italy and Raven Press, New York: Cortina International; 1990;p. 445–452
- Development of a new renal tubular agent, 99mTc-dimethylester of DTPA (DMDTPA): Preparation and evaluation of a lyophilized kit for 99mTc-DMDTPA. Ind J Nucl Med. 1996;11:227
- (abstr) A potential new cationic renal tubular agent: Evaluation in normal human volunteers of Tc-99m-diaminocyclohexane (DACH). J Nucl Med. 1992;33:923
- The uptake mechanisms of inflammation- and infection-localizing agents. Eur J Nucl Med. 1996;23:459–465
- Radiopharmaceuticals for the study of inflammatory processes: A review. Nucl Med Commun. 1997;18:437–455
- . Survey of radioactive agents for in-vitro labeling of phagocytic leukocytes. I. Soluble agents. J Nucl Med. 1976;17:480–487
- . Editorial: What is the best method for imaging focal infections?. J Nucl Med. 1990;31:413–416
- . Radiolabeling of blood cells: Methodology. In: Sampson CB editors. Textbook of Radiopharmacy: Theory and Practice. 2nd ed. Amsterdam: Gordon and Breach Science Pub; 1994;p. 75–86
- A method for stabilizing technetium-99m exametazime prepared from a commercial kit. Eur J Nucl Med. 1993;20:661–666
- Evaluation of 99mTc-ECD as a white blood cell labeling agent. Nucl Med Commun. 1997;18:540–542
- Biolocalization and cell labeling properties of neutral-lipophilic 99mTc-amine phenol chelates. Nucl Med Biol. 1990;18:167–172
- . 99mTc complexes for functional imaging: Genesis of development and recent trends. Ind J Nucl Med. 1998;13:79–94
- Retention of Technetium-99m in infectious foci in rats after release from Technetium-99m-labeled human non-specific polyclonal immunoglobulin G: A duallabel study with hydrazinonicotinamido and iminothiolano immunoglobulin. Eur J Nucl Med. 1996;23:1536–1539
- Tc-99m-human polyclonal IgG radiolabelled via the hydrazino nicotinamide derivative for imaging focal sites of infection of rats. J Nucl Med. 1990;31:2022–2028
- . 99mTc-labeled small peptides as diagnostic radiopharmaceuticals. Chem Rev. 1999;99:2235–2268
- Comparison of 99mTc-infecton imaging with radiolabeled white cell imaging in the evaluation of bacterial infection. Lancet. 1996;347:233–235
- Ciprofloxacin in imaging of infective versus sterile inflammation. Modern Trends in Radiopharmaceuticals for Diagnosis and Therapy. IAEA-TECDOC-1029, Vienna. 1998;213–220
- Technetium-99m-labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med. 2000;27:292–301
- Radiolabelled antimicrobial peptides for imaging of infection. Nucl Med Commun. 1998;19:1117–1121
- Ubiquicidin, a novel murine antimicrobial protein in the cytosolic fraction of activated macrophages. J Leucocyte Biol. 1999;66:423–428
- Inflammation and infection imaging with a 99mTc-neutrophil elastase inhibitor in monkeys. J Nucl Med. 2000;41:363–374
- Labeling peptides with Tc-99m using a bifunctional chelator of a N-hydroxy succinimide ester of mercaptoacetyl triglycine. J Nucl Med. 1998;39:56–64
- Neutrophil-specific 99mTc-labeled anti-CD15 monoclonal antibody imaging for diagnosis of equivocal appendicitis. J Nucl Med. 2000;412:449–455
- Technetium-99m-labeled anti-SSEA-1 antibody for human neutrophils: In vivo evaluation and assessment as an agent for imaging infectious diseases. J Nucl Med. 1996;37:1789–1795
- The design of pentavalent 99mTc-dimercaptosuccinate complex as a tumour imaging agent. Int J Nucl Med Biol. 1985;12:273–279
- Preparation and evaluation of 99mTc(V)-DMSA complex: Studies in medullary carcinoma of thyroid. Eur J Nucl Med. 1987;12:623–628
- Tumour imaging using Tc-99m-citrate. Ind J Nucl Med. 1997;12:77–83
- . The chemical identity of pentavalent technetium-99m-dimercaptosuccinic acid. J Nucl Med. 1991;32:845–849
- . Radiopharmaceuticals for oncology: Status and newer trends—An overview. Ind J Nucl Med. 1997;12:97–103
- Role of 201TlCl and 99mTc-sestamibi in tumour imaging. In: Freeman LM editors. Nuclear Medicine Annual. New York Press; 1994;p. 181–234
- Breast cancer detection with Tc-99m-Tetrofosmin. Clin Nucl Med. 1995;20:703–705
- Technetium-99m-d,l-hexamethylpropyleneamineoxime (HMPAO) uptake and glutathione content in brain tumors. J Nucl Med. 1991;32:1675–1681
- (abstr) Kinetics of 99mTc-GHA in human cerebral gliomas. Ind J Nucl Med. 1990;5:36
- Technetium-99m labeling of DNA oligonucleotides. J Nucl Med. 1995;36:2306–2314
- Non-invasive detection of hypoxic myocardium using fluorine-18-fluoromisonidazole and positron emission tomography. J Nucl Med. 1992;33:2202–2208
- TcO (PnAO-1-2-nitroimidazole) [BMS181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: Synthesis, characterization and xanthine oxidase-catalysed reduction. J Med Chem. 1994;37:9–17
- . Imaging ischemic tissue at risk of infarction during stroke. J Cereb Blood Flow Metab. 1993;13:755–762
- The synthesis and in vitro evaluation of a 99mTechnetium-nitroimidazole complex based on a bis(amine-phenol) ligand: Comparison to BMS-181321. J Med Chem. 1994;37:4155–4163
- Technetium-99m HL-91: A potential new marker of myocardial viability assessed by nuclear imaging early after reperfusion. J Nucl Cardiol. 1998;5:285–294
- Nicotinamide-substituted complexes as redox markers. I. Synthesis and UV estimation of rhenium and technetium mixed-ligand systems. J Labelled Compd Radiopharm. 1998;41:605–614
- Production of 99mTc radiopharmaceuticals for brain, heart and kidney imaging. In: IAEA TECDOC-805. Vienna: International Atomic Energy Agency; 1995;
- Chelating agents for the binding of metal ions to macromolecules. Nature. 1974;250:587–588
- Radiolabeling of monoclonal antibodies and fragments with technetium and rhenium. Bioconjugate Chem. 1992;3:91–99
- . In: Current Directions in Radiopharmaceutical Research and Development. London: Kluwer Academic Pub; 1996;
- Synthesis, characterization and x-ray structural determination of Technetium-(V)-oxotetradentate amine-oxime complexes. Inorg Chem. 1986;25:543–549
- A new class of oxotechnetium(V) chelate complexes containing a TcON2S2 core. Inorg Chem. 1981;20:1629–1632
- Synthesis and characterization of a series of isomeric oxotechnetium(V) diamidodithiolates. Inorg Chem. 1984;23:3793–3797
- Verona and Raven Press Synthesis and characterization of technetium and rhenium complexes of N,N′-1,2-ethylenediylbis-L-cysteine. Neurolite and its metabolites. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 3:New York: Cortina International; 1990;p. 433–444
- Synthesis and characterization and crystal structures of technetium(V) oxo complexes useful in nuclear medicine. I. Complexes of Mercaptoacetyl glycylglycylglycine MAG3 and its methyl ester derivative (MAG3OMe). Inorg Chem. 1995;34:1764–1772
- Technetium and rhenium complexes of mercapto-containing peptides. I. Tc(V) and Re(V) complexes with mercaptoacetyl diglycine (MAG2) and x-ray structure of AsPh4[TcO(MAG2)].C2H5OH. Inorg Chim Acta. 1993;210:209–214
- Synthesis and characterization of neutral oxotechnetium (V) bis aminoethane thiol complexes: Potential brain imaging agents. Polyhedron. 1992;11:1145–1155
- Rhenium (V) and Technetium (V) oxo complexes of an N2N′S peptidic chelator: Evidence of interconversion between the syn and anti conformations. Inorg Chem. 1997;36:5799–5808
- Synthesis and preliminary evaluation of a new chelate N2S4 for use in labeling proteins with metallic radionuclides. Nucl Med Biol. 1991;18:179–185
- Preparation and x-ray structure of trans-dioxo(1,4,8,11-tetraazacyclotetradecane) technetium(V) perchlorate hydrate. Inorg Chem. 1981;20:2386–2389
- Effect of ring size on properties of technetium amine complexes. X-ray structures of TcO2[Pent(AO)2] which contains an unusual eight-membered chelate ring and of TcOE-n(AO)2. Inorg Chem. 1987;26:3576–3582
- The production of 99mTc-labelled conjugated antibodies using a cyclam-based bifunctional chelating agent. Nucl Med Biol. 1987;14:569–577
- Radiolabelled somatostatin analogs in prostate cancer. Nucl Med Biol. 1997;24:105–113
- μ-oxo-bis-oxo complexes of Tc(V) with amine phenol ligands: Synthesis, characterization and x-Ray crystal structures. Inorg Chem. 1990;29:1850–1856
- Synthesis and characterization of Technetium (V) Oxo-complexes with quadridentate Schiff-base ligands: X-ray structures of μ-oxo-bis-{oxo[N,N′-propane-1,3-diyl-bis(salicylideneiminato)] technetium(V)} and chloro-oxo[N,N′-propane-1,3-diylbis(salicylideneiminato)] technetium(V). J Chem Soc Dalton Trans. 1984;2505–2511
- Low-symmetry, mixed-valent, μ-Oxo technetium complexes with pyridine and halide ligands. J Am Chem Soc. 1988;110:1818–1827
- . Dinuclear complexes of Re(V) with amine-phenol ligands. Syntheses, characterization and x-ray crystal structures. Polyhedron. 1994;13:701–708
- . Studies of Tc complexes 9. Use of tetrachloronitridotechnetate (VI) anion for the preparation of nitrido complexes of technetium. Crystal structure of bis(8-quinolinethiolato)nitridotechnetium(V). Inorg Chem. 1986;25:150–153
- Development of new technetium cores containing technetium-nitrogen multiple bonds. Synthesis and characterization of some diazenido-hydrazido-and imidocomplexes of technetium. Polyhedron. 1990;9:1497–1502
- . Formation of the Tc∖N multiple bond from the reaction of ammonium pertechnetate with S-methyl dithiocarbazate and its application to the preparation of technetium-99m-radiopharmaceuticals. J Chem Soc Dalton Trans. 1990;3729–3733
- . Synthesis and characterisation of the new neutral myocardial imaging agent [99mTcN(noet)2] (noet=N-ethyl-Nethoxydithiocarbamato). J Chem Soc Chem Commun. 1992;1354–1355
- . Technetium-99m dithiocarbamates as potential brain agents: Evaluation of aliphatic and amine containing analogues. Nucl Med Biol. 1989;16:721–725
- Monocapped tris(dioxime) complexes of Technetium (III): Synthesis and structural characterisation of TcX(dioxime)3B-R (R=CH3, C4H9)(X=Cl, Br; dioxime=Dimethylglyoxime, cyclohexanedione dioxime). Inorg Chem. 1989;28:3411–3416
- Synthesis and characterization of novel N3O3 Schiff base complexes of 99gTc and in vivo imaging studies with analogous 99mTc complexes. Nucl Med Biol. 1996;23:567–584
- Synthesis and radiochemical studies of 99mTc-complexes of polydentate tris-amineoximes. J Labelled Compd Radiopharm. 2000;43:1335–1344
- Technetium-99m-tetrofosmine as a new radiopharmaceutical for myocardial perfsion imaging. J Nucl Med. 1993;34:222–227
- Design and development of functionalized water-soluble phosphines: Catalytic and biomedical implications. Acc Chem Res. 1999;32:9–17
- In vitro and in vivo characterization of novel water soluble dithio-bis phosphine 99mTc complexes. Nucl Med Biol. 1997;24:685–691
- 99mTc-labeling and in vivo studies of a bombesin analogue with a novel water-soluble dithiadiphosphine based-bifunctional chelating agent. Bioconjugate Chem. 1999;10:254–260
- . A novel ternary ligand system for Tc-99m labeling of hydrazinonicotinamide-modified biologically active molecules using imine-N-containing heterocycles as coligands. Bioconjugate Chem. 1998;9:583–595
- . Potential technetium small molecule radiopharmaceuticals. Chem Rev. 1999;99:2205–2218
- The synthesis and characterisation of [MCl3(N=NC5H4NH)(HN=NC5H4N)] from [MO4]− (Where M=Re, Tc) or-ganodiazenido, organodiazene-chelate complexes. Inorg Chim Acta. 1996;252:421–426
- . Synthesis and characterization of organohydrazino complexes of technetium, rhenium and molybdenum with the {M(η1-HxNNR)(η2-HyNNR)} core and their relationship to radiolabeled organohydrazine-derivatized chemotactic peptides with diagnostic applications. The x-ray structure of [ReCl3(N=NC5H4NH)(HN=NC5H4N). Inorg Chem. 1996;37:2701–2716
- The synthesis and characterisation of technetium and rhenium hydrazinopyrimidine chelate complexes. J Chem Soc Dalton Trans. 1997;18:3185–3188
- New and versatile ternary ligand system for technetium radiopharmaceuticals: Water soluble phosphines and tricene as coligand labeling a hydrazinonicotinamide-modified cyclic glycoprotein IIb/IIIa. receptor antagonist with Tc-99m. Bioconjugate Chem. 1998;9:634
- Synthesis, evaluation and Tc-99m complexation of a hydrazinonicotinyl conjugate of GP IIb/IIIa antagonistic cyclic peptide for the detection of deep-vein thrombosis. Biorg Med Chem Lett. 1997;7:955–960
- A comparative evaluation of 99Tcm-HYNIC-HSA and 99Tcm-MAG3-HSA as possible blood pool agents. Nucl Med Commun. 1995;16:942–957
- Labeling of monoclonal antibodies with rhenium-186 using MAG3 chelate for radio-immunotherapy of cancer. A technical protocol. J Nucl Med. 1993;34:1953–1963
- . A peptide-base bifunctional chelating agent for 99mTc- and 186Re-labeling of monoclonal antibodies. Cancer Res. 1994;3:769–773
- Technetium-99m chelate-containing receptor-binding peptides. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine. Vol 4:Padova: SG Editoriale; 1995;p. 269–274
- Somatostatin receptor-binding peptides labeled with technetium-99m: Chemistry and initial biological studies. J Med Chem. 1996;39:1361–1371
- Thrombus imaging using Technetium-99m-labeled high-potency GP IIb/IIIa receptor antagonist. Chemistry and initial biological studies. J Med Chem. 1996;39:1372–1382
- 99mTc-labeling kinetics of four thiol-containing chelators and 2-hydrazinopyridine: Factor influencing their radiolabeling efficiency. Appl Radiat Isot. 1997;48:1103–1111
- . Bifunctional chelators for Technetium-99m. In: Mather SJ editors. Current Directions in Radiopharmaceutical Research and Development. London: Kluwer Academic Publisher; 1996;p. 31–46
- No carrier added preparations of “3+1” mixed-ligand 99mTc complexes. Appl Radiat Isot. 1998;49:5–11
- Stability versus reactivity of “3+1” mixed-ligands Technetium-99m complexes in vitro and in vivo. Eur J Nucl Med. 1998;25:793–796
- Reaction with the technetium and rhenium carbonyl complexes [NEt4][MX3(CO)3]. Synthesis and structure of [Tc(CN-rBu)3(CO)3][NO3] and [NEt4][Tc2(μ-SCH2CH2OH)3(CO)6]. Polyhedron. 1996;15:1079–1089
- Application of technetium and rhenium carbonyl chemistry to nuclear medicine. Transition Met Chem. 1997;22:597–601
- Potential of organometallic “[M(CO)3]+”(M=Re, Tc) fragment for the labeling of proteins and small molecules. Radiochim Acta. 1997;79:99–103
- Structural and 99Tc NMR investigations of complexes with fac-[Tc(CO)3]+ moieties and macrocyclic thioethers of various ring sizes: Synthesis and x-ray structure of the complexes fac-[Tc(9-ane-S3)(CO)3]Br, fac[Tc2(tosylate)2(18-ane-S6)(CO)6] and fac[Tc2(20-ane-S6-OH)(CO)6][tosylate]2. Inorg Chem. 1998;37:3509–3516
- Synthesis and structures of technetium (I) and rhenium (I) tricarbonyl complexes with bis(diphenylthiophosphoryl)amide, {M(CO)3[Ph2PS)2N](CH3CN)}(M=Tc, Re). Polyhedron. 1998;17:1303–1309
- Metal carbonyl synthesis XXII: Low-pressure carbonylation of [MOCl4−] and [MO4−]—The technetium(I) and rhenium (I) complexes [Et4N]2[MCl3(CO)3]. J Organomet Chem. 1995;492:217–224
- Multiple bonds between main group elements and transition metals. Synthesis and reactivity of TcCl(CO)3[P(C6H5)3]2: Novel technetium complex of 1,4,7-triazacyclononane and hydriditris(pyrazolyl) borate. Inorg Chem. 1992;31:895–899
- A simple single-step synthesis of [99Tc3H3(CO)12] from [99TcO4−] and its x-ray crystal structure. Application to the production of no-carrier added [188Re3H3(CO)12]. J Chem Soc Chem Commun. 1996;1291–1292
- Synthesis of rhenium(I) and technetium(I) carbonyl/dithioether ligand complexes bearing 3,17β-estradiol. Bioorg Med Chem Lett. 1997;7:2243–2246
- . Tc-99m-Markierung von cymantren-analogen verbindugen mit verschiedenen substituenten-Ein neuer zugang zu Tc-99m radiodiagnostika. J Labelled Compd Radiopharm. 1992;31:641–650
- Wenzel M, Schulze PE: Preparation of 99mTc-cyclopentadienyl technetium tricarbonyl complexes as diagnostic agents. PCT Int WO 91, 18908
- . Ester der 99mTc-markierten cytectrencarbonsaure mit alkoholen cylisher amine als gehirn-affine radiodiagnostica. J Labelled Compd Radiopharm. 1993;33:77–80
- Rhenium carbonyl complexes of β-estradiol derivatives with high affinity for estradiol receptors: An approach to selective organometallic radiopharmaceuticals. J Am Chem Soc. 1995;117:8372–8380
- . Synthesis of a tetradentate oxorhenium (V) complex mimic of a steroidal estrogen. J Org Chem. 1997;62:6290–6297
- . Preparation of cyclopentadienyltricarbonylrhenium complexes using a double ligand transfer reaction. Organometallics. 1998;17:2009–2017
- . A convenient three-component synthesis of substituted cyclopentadienyl tricarbonyl rhenium complexes. J Am Chem Soc. 1998;120:4514–4516
- . A convenient three-component synthesis of substituted cyclopentadienyl tricarbonyl Re(I) and Tc(I) complexes and its potential for radiolabeling. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium and Other Metals in Chemistry and Nuclear Medicin. Vol 5:Italy: SGE Editoriali; 1999;p. 109–116
- . Protein and peptide labeling with (cyclopentadienyl)tricarbonyl rhenium and technetium. Bioconjugate Chem. 1998;9:765–772
- Synthesis and biological evaluation of Tc-99m-cyclopentadienyltricarbonyltechnetium-labeled octreotide. Nucl Med Biol. 1999;26:1–7
- . A ticket to ride: Peptide radiopharmaceuticals. J Nucl Med. 1993;34:2253–2263
- . “Magic bullets”: From muskets to smart bombs. J Nucl Med. 1993;34:2264–2268
- . From monoclonal antibodies to peptides and molecular recognition units: An overview. J Nucl Med. 1993;34:533–536
- Peptide radiopharmaceuticals in nuclear medicine. Eur J Nucl Med. 1999;26:1511–1519
- . Recent developments in the radiolabeling of antibodies with iodine, indium and technetium. Semin Nucl Med. 1990;20:80–91
- . Antibody radiolabeling, problems and promises. Nucl Med Biol. 1990;17:49–55
- (abstr) . A novel approach to Tc-99m-labeled monoclonal antibodies. J Nucl Med. 1987;28:721
- . Reduction mediated technetium-99m-labeling of monoclonal antibodies. J Nucl Med. 1992;31:692–697
- Technetium-99m-labeled monoclonal antibodies; Evaluation of reducing agents. Nucl Med Biol. 1991;18:227–233
- Technetium-99m labeling of murine monoclonal antibody fragments. J Nucl Med. 1986;27:685–693
- European multicentre study of antimelanoma immunoscintigraphy by means of 99mTc-labelled monoclonal antibody fragments. Eur J Nucl Med. 1990;16:317–323
- New facile methods of stably labeling antibodies with technetium-99m. In: Nicolini M, Bandoli G, Mazzi U editor. Technetium and Rhenium in Chemistry and Nuclear Medicine, Vol 3. Cortina International. New York: Verona and Raven Press; 1990;p. 605–608
- (abstr) A rapid and efficient method of labeling IgG antibodies with Tc-99m and comparison to Tc-99m Fab' antibody fragments. J Nucl Med. 1989;30:793
- . 99mTc-labeled biotin conjugate in a tumor “pretargeting” approach with monoclonal antibodies. Angew Chem Int Ed Engl. 1992;31:1507–1509
- Synthesis, radiochemistry and biological evaluation of a new somatostatin analogue (SDZ-219-387) labeled with Technetium-99m. Eur J Nucl Med. 1994;21:437–444
- . Technetium-99m-labeled receptor-specific small-molecule radiopharmaceuticals: Recent developments and encouraging results. Nucl Med Biol. 1997;24:485–498
- . The development of estrogen and progestin radiopharmaceuticals for imaging breast cancer. Anticancer Res. 1997;17:1573–1576
- Progestin rhenium complexes: Metal-labeled steroids with high receptor-binding affinity, potential receptor directed agents for diagnostic-imaging or therapy. Bioconjugate Chem. 1991;2:353–366
- Progestin radiopharmaceuticals labeled with technetium and rhenium: Synthesis, binding affinity, and in-vivo distribution of a new progestin N2S2-metal conjugate. Bioconjugate Chem. 1994;5:182–193
- . Selective formation of heterodimeric bis-bidentate aminethiol-oxometal complexes of Rhenium(V). J Am Chem Soc. 1993;115:7045–7046
- Homodimeric and heterodimeric bis(aminethiol) oxometal complexes with Rhenium(V) and Technetium(V). Control of heterodimeric complex formation and an approach to metal complexes that mimic steroid hormones. J Med Chem. 1994;37:928–937
- Synthesis of oxorhenium(V) complexes derived from 7-alpha-functionalized testosterone derivatives. Eur J Inorg Chem. 1998;6:789–793
- . Synthesis of “3+1” mixed-ligand oxorhenium (V) complexes containing modified 3,17β-estradiol. Bioorg Med Chem Lett. 1996;6:2729–2734
- Relationship between lipophilicity and brain extraction of C-11-labelled radiopharmaceuticals. J Nucl Med. 1983;24:1030–1038
- [99mTc]TRODAT-1: A novel technetium-99m complex as a dopamine transporter imaging agent. Eur J Nucl Med. 1997;24:372–380
- Synthesis and characterisation of Tc-99m-labeled tropanes as dopamine transporter imaging agents. J Med Chem. 1997;40:9–17
- Specificity of diasteromers of [99mTc]TRODAT-1 as dopamine transporter imaging agents. J Med Chem. 1998;41:428–436
- Technepine: A high-affinity Tc-99m probe to label the dopamine transporter in brain by SPECT imaging. Synapse. 1996;22:239–246
- Novel rhenium complexes derived from α-Tropanol as potential ligands for the dopamine transporter. Bioorg Med Chem. 1998;6:1663–1672
- . TROTEC-1: A new high-affinity ligand for labeling of the dopamine transporter. J Med Chem. 1998;41:4429–4432
- Structural modification of receptor-binding technetium-99m complexes in order to improve brain uptake. Eur J Nucl Med. 1997;24:316–319
- Technetium(V) and Rhenium (V) complexes for 5-HT2A serotonin receptor binding: Structure affinity considerations. Nucl Med Biol. 1996;23:429–438
- Therapeutic approaches related to amyloid-β peptide and Alzheimer's disease. J Med Chem. 1995;38:4141–4154
- . Technetium complexes for the quantitation of brain amyloid. J Am Chem Soc. 1996;118:4506–4507
PII: S0001-2998(01)80006-4
doi: 10.1053/snuc.2001.26205
© 2001 Published by Elsevier Inc.
« Previous
Next »
Seminars in Nuclear Medicine
Volume 31, Issue 4
, Pages 260-277
, October 2001
