Seminars in Nuclear Medicine
Volume 31, Issue 4 , Pages 278-285, October 2001

Newer methods of labeling diagnostic agents with Tc-99m

  • Ronnie C. Mease

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Ronnie C. Mease, PhD, Department of Diagnostic Radiology, Division of Nuclear Medicine, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201.
    • ,
  • Carol Lambert

The past several years have seen marked advances in technetium/rhenium chemistry applicable to the preparation of new 99mTc-labeled radiopharmaceuticals. This article focuses on recent developments in technetium chemistry, including the preparation of “3+1” complexes, the preparation and use of (99mTc[CO]3)+ complexes for labeling biomolecules, the preparation of rhenium steroid inclusion complexes, improvements in both hydrazinonicotinamide labeling chemistry and in the preformed 99mTc complex method of labeling biomelecules, and new solid-phase separation techniques that may allow the isolation of high specific-activity radiopharmaceuticals in a clinical setting.

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PII: S0001-2998(01)80007-6

doi:10.1053/snuc.2001.26182

Seminars in Nuclear Medicine
Volume 31, Issue 4 , Pages 278-285, October 2001

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