Seminars in Nuclear Medicine
Volume 31, Issue 1 , Pages 69-81 , January 2001

Bone densitometry and the diagnosis of osteoporosis

  • Glen M. Blake

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Glen M. Blake, PhD, Department of Nuclear Medicine, Guy's Hospital, St. Thomas Street, London, England SE1 9RT.
  • ,
  • Ignac Fogelman

References 

  1. Genant HK, Engelke K, Fuerst T, et al. Noninvasive assessment of bone mineral and structure: State of the art. J Bone Miner Res. 1996;11:707–730
  2. Blake GM, Fogelman I. Technical principles of dual energy x-ray absorptiometry. Semin Nucl Med. 1997;27:210–228
  3. Kanis JA, Delmas P, Burckhardt P, et al. Guidelines for diagnosis and treatment of osteoporosis. Osteoporos Int. 1997;7:390–406
  4. Jacobsen SJ, Goldberg J, Miles TP, et al. Race and sex differences in mortality following fracture of the hip. Am J Public Health. 1992;82:1147–1150
  5. Koval KJ, Skovron ML, Ahanonoff GB, et al. Ambulatory ability after hip fracture: A prospective study in geriatric patients. Clin Orthop. 1995;310:150–159
  6. Ray NF, Chan JK, Thamer M, et al. Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: Report from the National Osteoporosis Foundation. J Bone Miner Res. 1997;12:24–35
  7. Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent fractures in elderly women. N Engl J Med. 1992;327:1637–1642
  8. Black DM, Cummings SR, Karpf DB, et al. Randomised trial of the effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet. 1996;348:1535–1541
  9. Ettinger B, Black DM, Mitlak BH, et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: Results from a 3-year randomized clinical trial. JAMA. 1999;282:637–645
  10. Reginster J-Y, Minne HW, Sorensen OH, et al. Randomised trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Osteoporos Int. 2000;11:83–91
  11. In: Consensus Development Conference: Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med. 94:1993;p. 646–650
  12. In: WHO Technical Report Series 843. Geneva: World Health Organization; 1994;
  13. Kanis JA, Melton LJ, Christiansen C, et al. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1137–1141
  14. Blake GM, Fogelman I. Interpretation of bone densitometry studies. Semin Nucl Med. 1997;27:248–260
  15. Grampp S, Genant HK, Mathur A, et al. Comparisons of non-invasive bone mineral measurements in assessing age-related loss, fracture discrimination and diagnostic classification. J Bone Miner Res. 1997;12:697–711
  16. Blake GM, Wahner HW, Fogelman I. In: ed 2. The Evaluation of Osteoporosis: Dual Energy X-ray Absorptiometry and Ultrasound in Clinical Practice. London, England: Martin Dunitz; 1999;
  17. Njeh CF, Hans D, Fuerst T, et al. In: Quantitative Ultrasound: Assessment of Osteoporosis and Bone Status. London, England: Martin Dunitz; 1999;
  18. Cann CE. Quantitative CT for determination of bone mineral density: A review. Radiology. 1988;166:509–522
  19. Glüer C-C, Jergas M, Hans D. Peripheral measurement techniques for the assessment of osteoporosis. Semin Nucl Med. 1997;27:229–247
  20. Njeh CF, Fuerst T, Hans D, et al. Radiation exposure in bone mineral assessment. Appl Radiat Isot. 1999;50:215–236
  21. Cummings SR, Black DM, Nevitt MC, et al. Bone density at various sites for prediction of hip fractures. Lancet. 1993;341:72–75
  22. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. 1996;312:1254–1259
  23. (abstr) Black DM, Palermo L, Bauer D. How well does bone mass predict long-term risk of hip fracture?. Osteoporos Int. 2000;11(suppl 2):S59
  24. Eastell R. Treatment of postmenopausal osteoporosis. N Engl J Med. 1998;338:736–746
  25. Can CE, Genant HK, Kolb FO, et al. Quantitative computed tomography for prediction of vertebral fracture risk. Bone. 1985;6:1–7
  26. Kalender WA. Effective dose values in bone mineral measurements by photon absorptiometry and computed tomography. Osteoporos Int. 1992;2:82–87
  27. Patel R, Blake GM, Fogelman I. Radiation dose to the patient and operator from a peripheral dual x-ray absorptiometry system. J Clin Densitom. 1999;2:397–401
  28. Faulkner KG. Bone densitometry: Choosing the proper skeletal site to measure. J Clin Densitom. 1998;1:279–285
  29. Njeh CF, Boivin CM, Langton CM. The role of ultrasound in the assessment of osteoporosis: A review. Osteoporos Int. 1997;7:7–22
  30. Hans D, Dargent-Molina P, Schott AM, et al. Ultrasonographic heel measurements to predict hip fracture in elderly women: The EPIDOS prospective study. Lancet. 1996;348:511–514
  31. Bauer DC, Glüer C-C, Cauley JA, et al. Broadband ultrasonic attenuation predicts fractures strongly and independently of densitometry in older women. Arch Intern Med. 1997;157:629–634
  32. Pluijm SMF, Graafmans WC, Bouter LM, et al. Ultrasound measurements for the prediction of osteoporotic fractures in elderly people. Osteoporos Int. 1999;9:550–556
  33. Kanis JA, Glüer C-C. An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int. 2000;11:192–202
  34. (abstr) Black DM. Revision of T-score BMD diagnostic thresholds. Osteoporos Int. 2000;11(suppl 2):S58
  35. Jergas M, Glüer C-C. Assessment of fracture risk by bone density measurements. Semin Nucl Med. 1997;27:261–275
  36. Altman DG. In: Practical Statistics for Medical Research. London, England: Chapman & Hall; 1991;
  37. Glüer C-C. Quantitative ultrasound techniques for the assessment of osteoporosis—Expert agreement on current status. J Bone Miner Res. 1997;12:1280–1288
  38. National Osteoporosis Foundation . Osteoporosis: Review of the evidence for prevention, diagnosis, and treatment and cost-effectiveness analysis. Osteoporos Int. 1998;8(suppl 4):S7–S80
  39. Faulkner KG, VonStetton E, Miller P. Discordance in patient classification using T-scores. J Clin Densitom. 1999;2:343–350
  40. Delmas PD. Do we need to change the WHO definition of osteoporosis?. Osteoporos Int. 2000;11:189–191
  41. Miller PD. Controversies in bone mineral density diagnostic classifications. Calcif Tissue Int. 2000;66:317–319
  42. Blake GM, Patel R, Fogelman I. Peripheral or axial bone density measurements?. J Clin Densitom. 1998;1:55–63
  43. Looker AC, Wahner HW, Dunn WL, et al. Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int. 1998;8:468–489
  44. Frost ML, Blake GM, Fogelman I. Contact quantitative ultrasound: An evaluation of precision, fracture discrimination, age-related bone loss and applicability of the WHO criteria. Osteoporos Int. 1999;10:441–449

PII: S0001-2998(01)80033-7

doi: 10.1053/snuc.2001.18749

Seminars in Nuclear Medicine
Volume 31, Issue 1 , Pages 69-81 , January 2001