Seminars in Nuclear Medicine
Volume 32, Issue 2 , Pages 92-96, April 2002

Somatostatin receptor imaging of non-small cell lung cancer with 99mTc depreotide

  • Yusuf Menda

      Affiliations

    • Division of Nuclear Medicine, University of Iowa College of Medicine Iowa City, IA, USA
    • Veterans Affairs Medical Center, Iowa City, IA, USA
    • Corresponding Author InformationAddress reprint requests to Yusuf Menda, MD, 3858 JPP, 200 Hawkins Dr, University of Iowa Hospitals and Clinics, Iowa City, IA 52246 Copyright 2002, Elsevier Science (USA). All rights reserved.
    • ,
  • Daniel Kahn

      Affiliations

    • Division of Nuclear Medicine, University of Iowa College of Medicine Iowa City, IA, USA
    • Veterans Affairs Medical Center, Iowa City, IA, USA

Several tumors overexpress somatostatin receptors (SSTR) and can thus be imaged with radiolabeled analogues of somatostatin. Tc-99m depreotide is a new radiolabeled somatostatin analogue that shows high affinity for SSTR2, SSTR3, and SSTR5 subtypes. It has been recently FDA-approved for use in the evaluation of indeterminate solitary pulmonary nodules. SPECT with Tc-99m depreotide is highly accurate in this clinical setting and may be preferable to FDG-PET because of its lower cost and wider availability. Large studies are also underway to evaluate the accuracy of Tc-99m depreotide in staging of lung cancer.

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PII: S0001-2998(02)80027-7

doi:10.1053/snuc.2002.31564

Seminars in Nuclear Medicine
Volume 32, Issue 2 , Pages 92-96, April 2002

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