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Seminars in Nuclear Medicine
Volume 34, Issue 1
, Pages 32-46
, January 2004
Imaging and therapy of tumors induced to express somatostatin receptor by gene transfer using radiolabeled peptides and single chain antibody constructs
References
- . Experimental radioimmunotherapy. Med Phys. 1993;20:551–567
-
.
Experimental radioimmunotherapy and methods to increase therapeutic efficacy.
In:
Goldenberg DM editors. Cancer Therapy with Radiolabeled Antibodies. Boca Raton, FL: CRC Press; 1995;p. 115–140
- . Overview of studies on experimental radioimmunotherapy. Cancer Res. 1995;55(suppl):5832s–5836s
- . Status of radioimmunotherapy in the new millennium. Cancer Biother Radiopharm. 2001;16:237–256
- . Targeted therapy of cancer with radiolabeled antibodies. J Nucl Med. 2002;43:693–713
- . Radiolabeled anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoma. J Clin Oncol. 2002;20:3545–3557
- . Radioimmunotherapy of B-cell non-Hodgkin’s lymphoma (From clinical trials to clinical practice). J Nucl Med. 2002;43:1507–1529
- Multicenter phase II study of iodine-131 tositumomab for chemotherapy-relapsed/refractory low-grade and transformed low-grade B-cell non-Hodgkin’s lymphomas. J Clin Oncol. 2000;18:1316–1323
- A phase I/II trial of iodine-131-tositumomab (anti-CD20), etoposide, cyclophosphamide, and autologous stem cell transplantation for relapsed B-cell lymphomas. Blood. 2000;96:2934–2942
- Pivotal study of iodine I 131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin’s lymphomas. J Clin Oncol. 2001;19:3918–3928
- Ibritumomab tiuxetan radioimmunotherapy for patients with relapsed or refractory non-Hodgkin lymphoma and mild thrombocytopenia (A phase II multicenter trial). Blood. 2002;99:4336–4342
- Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin’s lymphoma. J Clin Oncol. 2002;20:2453–2463
- Radioimmunotherapy with intravenously administered 131I-labeled chimeric monoclonal antibody MOv18 in patients with ovarian cancer. J Nucl Med. 2000;41:1168–1176
- Intraperitoneal radioimmunochemotherapy of ovarian cancer (A phase I study). Cancer Biother Radiopharm. 2001;16:305–315
- A phase I study of combined modality 90Yttrium-CC49 intraperitoneal radioimmunotherapy for ovarian cancer. Clin Cancer Res. 2002;8:2806–2811
-
.
The treatment of patients with recurrent malignant gliomas with intratumoral radioimmunoconjugates.
Recent Results Cancer Res. 1996;141:141–159
- Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas. J Clin Oncol. 2000;18:3862–3872
- . Somatostatin receptor imaging of non-small cell lung cancer with 99mTc depreotide. Semin Nucl Med. 2002;32:92–96
- . Radiolabeled peptides in diagnosis and tumor imaging (Clinical overview). Semin Nucl Med. 2002;32:79–83
- . Peptide and antibody imaging in lung cancer. Semin Nucl Med. 2002;32:276–292
- Vasoactive intestinal peptide receptor scintigraphy. J Nucl Med. 1995;36:1732–1739
- Octreotide. N Engl J Med. 1996;334:246–254
- . The utility of a somatostatin-type receptor binding peptide radiopharmaceutical (P829) in the evaluation of solitary pulmonary nodules. Chest. 1999;115:224–232
- 111In-DOTA-lanreotide scintigraphy in patients with tumors of the lung. J Nucl Med. 2001;42:1309–1315
- Experimental radiotherapy of receptor-positive human prostate adenocarcinoma with 188Re-RC-160, a directly-radiolabeled somatostatin analogue. Int J Cancer. 1996;65:214–220
- Radiotherapy, toxicity and dosimetry of copper-64-TETA-octreotide in tumor-bearing rats. J Nucl Med. 1998;39:1944–1951
- . The somatostatin receptor-targeted radiotherapeutic [90Y-DOTA-DPhe1, Tyr3]octreotide (90Y-SMT 487) eradicates experimental rat pancreatic CA 20948 tumours. Eur J Nucl Med. 1998;25:668–674
- Tumor response after [90Y-DOTA0, Tyr3]octreotide radionuclide therapy in a transplantable rat tumor model is dependent on tumor size. J Nucl Med. 2001;42:1841–1846
- Radiotherapeutic efficacy of 153Sm-CMDTPA-Tyr3-octreotate in tumor-bearing rats. Nucl Med Biol. 2001;28:327–334
-
90Y-DOTATOC treatment of patients with SSTr2 positive tumors (Preliminary results of phase I-II study).
J Nucl Med. 1999;40:18P
- . New advances in peptide receptor radionuclide therapy. J Nucl Med. 2002;43:617–620
- Somatostatin receptor-targeted radionuclide therapy of tumors (Preclinical and clinical findings). Semin Nucl Med. 2002;32:133–140
-
.
Human immune response to monoclonal antibodies.
J Immunother. 1994;15:42–52
- Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms. Cancer Res. 1992;52:3402–3408
- Direct comparison of a radioiodinated intact chimeric anti-CEA MAb with its F(ab′)2 fragment in nude mice bearing different human colon cancer xenografts. Br J Cancer. 1993;68:684–690
- Targeting c-erbB-2 expressing tumors using single-chain Fv monomers and dimers. Cancer Res. 1995;55(suppl):5983s–5989s
- Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab’ antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum (Results of a pivotal, phase III trial). J Clin Oncol. 1996;14:2295–2305
- . A ticket to ride (Peptide radiopharmaceuticals). J Nucl Med. 1993;34:2253–2263
- Antibody-guided localization of intraperitoneal tumors following intraperitoneal or intravenous antibody administration. Cancer Res. 1987;47:6528–6531
- Monoclonal antibody and F(ab′)2 fragment delivery to tumor in patients with glioma (Comparison of intracarotid and intravenous administration). Cancer Res. 1990;50:4105–4110
- Intraperitoneal indium-111- and yttrium-90-labeled human IgM (AC6C3-2B12) in nude mice bearing peritoneal carcinomatosis. J Nucl Med. 1996;37:1545–1551
- Effect of metabolism on retention of indium-111-labeled monoclonal antibody in liver and blood. J Nucl Med. 1994;35:1851–1857
- Stability of a metabolizable ester bond in radioimmunoconjugates. Nucl Med Biol. 1996;23:129–136
- Interferon-induced changes in pharmacokinetics and tumor uptake of 111In-labeled antimelanoma antibody 96.5 in melanoma patients. J Natl Cancer Inst. 1988;80:160–165
-
.
γ-Interferon enhancement of a multiple treatment regimen for radioimmunotherapy.
Antibody Immunoconj Radiopharm. 1991;4:837–845
- Improved radioimmunotherapeutic efficacy of an anticarcinoma monoclonal antibody (131I-CC49) when given in combination with γ-interferon. Cancer Res. 1993;53:600–608
- Systemic administration of recombinant interferon alfa in carcinoma patients upregulates the expression of the carcinoma-associated antigens tumor-associated glycoprotein-72 and carcinoembryonic antigen. J Clin Oncol. 1996;14:2031–2042
- Enhancement of radiolabeled antibody binding and tumor localization through adenoviral transduction of the human carcinoembryonic antigen gene. Gene Ther. 1996;3:567–580
- Localization of iodine-125-mIP-Des-Met14-bombesin (7–13)NH2 in ovarian carcinoma induced to express the gastrin releasing peptide receptor by adenoviral vector-mediated gene transfer. J Nucl Med. 1997;38:1221–1229
- Adenoviral mediated delivery of gastrin releasing peptide receptor results in specific tumor localization of a bombesin analogue in vivo. Clin Cancer Res. 1997;3:1187–1194
- Tumor localization of a radiolabeled bombesin analogue in mice bearing human ovarian tumors induced to express the gastrin releasing peptide receptor by an adenoviral vector. Cancer. 1997;80:2419–2424
- Therapeutic efficacy of anti-Lewisy humanized 3S193 radioimmunotherapy in a breast cancer model (Enhanced activity when combined with taxol chemotherapy). Clin Cancer Res. 2000;6:3621–3628
- Combined modality radioimmunotherapy for human prostate cancer xenografts with taxanes and 90Yttrium-DOTA-peptide-ChL6. Prostate. 2002;50:27–37
- Preliminary report of a phase I study of combination chemotherapy and humanized A33 antibody immunotherapy in patients with advanced colorectal cancer. Clin Cancer Res. 2003;9:1347–1353
- Cooperative effect of radioimmunotherapy and antiangiogenic therapy with thalidomide in human cancer xenografts. J Nucl Med. 2002;43:1084–1089
- Synergy between vascular targeting agents and antibody-directed therapy. Int J Radiat Oncol Biol Phys. 2002;54:1524–1531
- Cilengitide targeting of αvβ3 integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts. Cancer Res. 2002;62:4263–4272
-
Genetic induction of antigens and receptors as targets for cancer radiotherapy.
Tumor Targeting. 1998;3:122–137
-
Enhanced in vivo gene delivery to human ovarian cancer xenografts utilizing a tropism-modified adenovirus vector.
Tumor Targeting. 1998;3:25–31
- In vivo localization of [111In]-DTPA-D-Phe1-octreotide to human ovarian tumor xenografts induced to express the somatostatin receptor subtype 2 using an adenoviral vector. Clin Cancer Res. 1999;5:383–393
- . The type 2 human somatostatin receptor as a platform for reporter gene imaging. Eur J Nucl Med. 2002;29:388–399
-
Localization of Cu-64-TETA-octreotide to human ovarian cancer xenografts induced to express SSTr2 with an adenoviral vector.
J Nucl Med. 1998;39:63P
-
Bonner, JA, Buchsbaum, DJ, Russo, SM, et al: A gene therapy-based approach for increasing tumor cell expression of epidermal growth factor receptor (EGFr). Semin Radiat Oncol (in press)
- Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization. Cancer Res. 1994;54:3455–3459
-
.
The role of radiolabeled somatostatin analogs in the management of cancer patients.
In:
DeVita VT, Hellman S, Rosenberg SA editor. Principles and Practice of Oncology, PPO Updates, vol 9. (ed 4).. Philadelphia, PA: Lippincott-Raven; 1995;p. 1–16
- Somatostatin receptors in human prostate and prostate cancer. J Clin Endocrinol Metab. 1995;80:2806–2814
- Metastatic hormone-refractory prostatic adenocarcinoma expresses somatostatin receptors and is visualized in vivo by [111In]-labeled DTPA-D-[Phe1]-octreotide scintigraphy. Cancer Res. 1995;55(suppl):5805s–5810s
- High expression of somatostatin receptors and messenger ribonucleic acid for its receptor subtypes in organ-confined and locally advanced human prostate cancers. J Clin Endocrinol Metab. 2000;85:2564–2571
- . Somatostatin and its receptor family. Front Neuroendocrinol. 1999;20:157–198
- Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992;89:251–255
- Classification and nomenclature of somatostatin receptors. Trends Pharmacol Sci. 1995;16:86–88
- Cloning, expression and pharmacological characterisation of the mouse somatostatin sst(5) receptor. Neuropharmacology. 2000;39:1451–1462
- Somatostatin receptor subtype specificity and in vivo binding of a novel tumor tracer, 99mTc-P829. Cancer Res. 1998;58:1850–1859
- Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000;27:273–282
- . Oncological applications of somatostatin analogues. Cancer Res. 1988;48:6977–6985
- Molecular pharmacology of somatostatin-receptor subtypes. Ann N Y Acad Sci. 1994;733:138–146
- Loss of sst2 somatostatin receptor gene expression in human pancreatic and colorectal cancer. Cancer Res. 1996;56:1823–1827
-
Synthesis, radiolabelling, and evaluation of DTPA/octreotide conjugates for radiotherapy.
J Labelled Comp Radiopharm. 1995;37:499–501
-
Radiotherapy with yttrium-90 labeled DOTA-Tyr3-octreotide in tumor bearing rodents.
J Nucl Med. 1997;38:18P
- Response to treatment with yttrium 90-DOTA-lanreotide of a patient with metastatic gastrinoma. J Nucl Med. 1998;39:2090–2094
- Receptor-mediated radionuclide therapy with 90Y-DOTA-D-Phe1-Tyr3-Octreotide (Preliminary report in cancer patients). Cancer Biother Radiopharm. 1999;14:477–483
- Biodistribution of Y-86-DOTA-Tyr3-octreotide (SMT487) and renal protective effect of amino acid infusion (A phase I study). Eur J Nucl Med. 1998;25:837
- OctreoTher™ (Ongoing early clinical development of a somatostatin-receptor-targeted radionuclide antineoplastic therapy). Digestion. 2000;62(suppl 1):69–72
-
Phase I study of therapy with 90Y-SMT487 (octreother) in patients with somatostatin receptor (SS-R) positive tumors.
J Nucl Med. 2002;5:33P
-
Peptide receptor radionuclide therapy (PRRT) with 90Y-DOTA0, Tyr3-octreotide (Y-Oc) and 111In-DTPA0-octreotide (In-Oc) (Comparison of tumor response and toxicity).
J Nucl Med. 2002;5:34P
-
Treating somatostatin receptor positive tumours with 90Y-lanreotide.
J Nucl Med. 2002;5:34P
-
Treatment with 177Lu-DOTA-Tyr3-octreotate in patients with somatostatin receptor positive tumors.
J Nucl Med. 2002;5:34P
- In situ use of suicide genes for cancer therapy. Semin Oncol. 1996;23:31–45
- . Enzyme/prodrug-based tumor vaccination (All politics (and immunity) are local). J Natl Cancer Inst. 1999;91:1986–1989
- . Radiosensitizing nucleosides. J Natl Cancer Inst. 1996;88:1193–1203
- Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase. Mol Microbiol. 1992;6:1335–1344
- . A first step in the development of gene therapy for colorectal carcinoma (Cloning, sequencing, and expression of escherichia coli cytosine deaminase). Mol Pharmacol. 1993;43:380–387
-
Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model.
Radiation Res. 1999;152:499–507
- Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase. Hum Gene Ther. 1999;10:1993–2003
- In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res. 1993;53:4619–4626
-
In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine.
Human Gene Ther. 1995;6:1055–1063
- . Metabolic suicide genes in gene therapy. Pharmacol Ther. 1994;63:199–207
- Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with cytosine deaminase gene (Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase). Proc Natl Acad Sci U S A. 1994;91:8302–8306
-
In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine.
Human Gene Ther. 1996;7:713–720
- Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. Surgery. 1994;116:205–213
- Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. Cancer Res. 1997;57:4205–4209
- Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo. Cancer Res. 1997;57:4325–4332
- Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models. Gene Ther. 2000;7:1019–1026
- Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminease gene. Clin Cancer Res. 1996;2:53–57
- Selective in vivo radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells transduced with the E. coli cytosine deaminase (CD) gene. Int J Radiat Oncol Biol Phys. 1998;41:883–887
- Combining cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells. J Gastrointest Surg. 1998;2:283–291
-
Pederson LC, Stackhouse, MA, Vickers, SM, et al: Redirection of cytosine deaminase gene transfer via basic fibroblast growth factor receptor enhances pancreatic carcinoma and cholangiocarcinoma cytotoxicity mediated by conversion of 5-fluorocytosine to 5-fluorouracil. Ann Surg (submitted)
- . Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver. Hum Gene Ther. 1996;7:1567–1576
- Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. Cancer Res. 2002;62:773–780
- Genetic prodrug activation therapy for breast cancer (A phase I clinical trial of erbB-2-directed suicide gene expression). J Clin Oncol. 1999;17:2180–2189
- A surface expression vector for antibody screening. Gene. 1991;104:147–153
- Recombinant human monoclonal antibodies. Basic principles of the immune system transferred to E. coli. Cell Biophys. 1992;21:81–91
- Minibody (A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts). Cancer Res. 1996;56:3055–3061
- . “Diabodies” (Small bivalent and bispecific antibody fragments). Proc Natl Acad Sci U S A. 1993;90:6444–6448
-
Anti-carcinoembryonic antigen (CEA) diabody for rapid tumor targeting and imaging.
Tumor Targeting. 1999;4:47–58
- Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody (comparison to radioiodinated fragments). Bioconjug Chem. 2001;12:220–228
- High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment. Proc Natl Acad Sci U S A. 2000;97:8495–8500
- High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules. Cancer Res. 2001;61:4750–4755
- . Gene therapy for the treatment of cancer. Cancer Biother Radiopharm. 2001;16:275–288
- . Gene transfer strategies for improving radiolabeled peptide imaging and therapy. Q J Nucl Med. 2000;44:208–223
- Targeted radiotherapy with [90Y]-SMT 487 in mice bearing human non-small cell lung tumor xenografts induced to express human somatostatin receptor subtype 2 with an adenoviral vector. Cancer. 2002;94:1298–1305
- Noninvasive monitoring of gene transfer using a reporter receptor imaged with a high affinity peptide radiolabeled with 99mTc or 188Re. J Nucl Med. 2000;41:887–895
-
Tumor regression in rat pancreatic (AR42J) tumor-bearing mice with Re-188 P2045—A somatostatin analog.
Clin Cancer Res. 1999;5:3769s
- A noninvasive reporter system to image adenoviral-mediated gene transfer to ovarian cancer xenografts. Gynecol Oncol. 2001;83:432–438
- Gamma camera dual imaging with a somatostatin receptor and thymidine kinase after gene transfer with a bicistronic adenovirus. Radiology. 2002;223:417–425
-
An Ad-based strategy for imaging, radiotherapy, and enhanced tumor killing.
Mol Ther. 2001;3:S25
- Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Mol Ther. 2002;6:73–82
- Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression. J Nucl Med. 2002;43:1072–1083
- . Molecular imaging and cancer. Mol Cancer Ther. 2003;2:335–343
☆ This work was supported by DOE grant DE-FG05 93ER61654.
PII: S0001-2998(03)00071-0
doi: 10.1053/j.semnuclmed.2003.09.005
© 2004 Elsevier Inc. All rights reserved.
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Seminars in Nuclear Medicine
Volume 34, Issue 1
, Pages 32-46
, January 2004
