Seminars in Nuclear Medicine
Volume 34, Issue 1 , Pages 70-82, January 2004

Neurochemical imaging of dementias☆

  • Satoshi Minoshima

      Affiliations

    • Departments of Radiology and Bioengineering, University of Washington, Seattle, WA, USA
    • Corresponding Author InformationAddress reprint requests to Satoshi Minoshima, MD, PhD, Department of Radiology, University of Washington, Health Sciences Bldg., NW040J, 1959 N.E. Pacific St., Box 356004, Seattle, WA 98195-6004, USA
    • ,
  • Kirk A Frey

      Affiliations

    • Department of Radiology, University of Michigan, Ann Arbor, MI, USA
    • ,
  • Donna J Cross

      Affiliations

    • Washington National Primate Research Center, University of Washington, Seattle, WA, USA
    • ,
  • David E Kuhl

      Affiliations

    • Department of Radiology, University of Michigan, Ann Arbor, MI, USA

Abstract 

Neurochemical imaging is one of the most established “molecular” imaging techniques. There have been tremendous efforts expended to develop radioligands specific to each neurochemical system. Investigational applications of neurochemical imaging in dementing disorders are extensive. Cholinergic, dopaminergic, and serotonergic systems, as well as benzodiazepine receptors, opioid receptors, and glutamatergic receptors have been imaged in Alzheimer disease and other dementing disorders. These investigations have provided important insights into disease processes in living human patients. The clinical diagnostic use of neurochemical imaging for dementing disorders is currently limited, but this technique is used to help develop therapeutic drugs at multiple levels.

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☆ This work was supported by NIH grants RO1-NS24896, PO1-NS15655, and RO1 NS045254.

PII: S0001-2998(03)00074-6

doi:10.1053/j.semnuclmed.2003.09.008

Seminars in Nuclear Medicine
Volume 34, Issue 1 , Pages 70-82, January 2004

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