Normal patterns and variants in single-photon emission computed tomography and positron emission tomography brain imaging
Article Outline
One of the most important issues in evaluating functional brain scans for research or clinical purposes is to be able to identify normal variants. Determining the baseline “normal” state of the brain is not easy to characterize since many normal brain functions and mental processes affect brain activity. This article reviews issues pertaining to the technical and neurophysiological aspects of functional brain imaging that might alter “normal” activity and will also consider how normal brain activity changes throughout the lifespan.
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References
- . Image separation of radioisotope scanning. Radiology. 1963;80:653–662
- The MARK IV system for radionuclide computed tomography of the brain. Radiology. 1976;121:405–413
- . Studies of central nervous system disorders with single photon emission computed tomography and positron emission tomography. Evolution over the past 2 decades. In: Semin Nucl Med. 21:1991;p. 58–81
- In: Diksic M, Reba RC editor. Radiopharmaceuticals and Brain Pathology Studied With PET and SPECT. Boca Raton, FL: CRC Press; 1991;
- . Overview of radiopharmaceuticals for diagnosis of central nervous disorders. Crit Rev Clin Lab Sci. 1991;28:269–286
- Labeled 2-deoxyglucose analogs. 18F-labeled 2-deoxyglucose-2-fluoro-d-glucose, 2-deoxy-2-fluoro-d-manose and 14C-2-deoxy-2-deoxy-2 fluoro-d-glucose. J Label Comp Radiopharm. 1978;14:175–183
- A positron emission transaxial tomography for nuclear medicine imaging (PET). Radiology. 1975;114:89–98
- Design considerations for a positron emission transaxial tomography (PET-III). IEEE Trans Nucl Sci. 1976;23:516–522
- . Preliminary report of performance of high resolution gadalinium orthosilicate (GSO)-based dedicated brain PET scanner. J Nucl Med. 2002;29:296P
- . Determination of regional cerebral function with FDG-PET imaging in neuropsychiatric disorders. In: Semin Nucl Med. 32:2002;p. 13–34
- . Single photon emission computed tomography in Alzheimer's disease and related disorders. In: George A editors. Neuroimaging Clinics of North America. vol 5:Philadelphia, PA: WB Saunders Co; 1995;p. 103–123
- Baseline, visual deprivation and visual stimulation 99Tcm-HMPAO-related changes in visual cortex can be detected with a single-head SPET system. Nucl Med Commun. 1996;17:480–484
- Tomographic mapping of human cerebral metabolism: Visual stimulation and deprivation. Neurol. 1981;31:517–529
- Areas of the human brain activated by ambient visual motion, indicating three kinds of self-movement. Exp Brain Res. 2002;143:78–88
- Movement and mind: A functional imaging study of perception and interpretation of complex intentional movement patterns. Neuroimage. 2000;12:314–325
- (suppl) . Human sensory stimulation and deprivation: Positron emission tomographic results and strategies. Ann Neurol. 1984;15:S50–S60
- . When that tune runs through your head: A PET investigation of auditory imagery for familiar melodies. Cereb Cortex. 1999;9:697–704
- An fMRI investigation of emotional engagement in moral judgment. Science. 2001;293:2105–2108
- . Differential activation of right superior parietal cortex and intraparietal sulcus by spatial and nonspatial attention. Neuroimage. 1998;8:176–187
- The measurement of regional cerebral blood flow during the complex cognitive task of meditation: A preliminary SPECT study. Psychiatry Res. 2001;106:113–122
- . Localization of a human system for sustained attention by positron emission tomography. Nature. 1991;349:61–64
- . Functional heterogeneity in cingulate cortex: The anterior executive and posterior evaluative regions. Cereb Cortex. 1992;2:435–443
- Neuroanatomical correlates of externally and internally generated human emotion. Am J Psychiatry. 1997;154:918–925
- Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. Neuroimage. 2002;16:331–348
- Mu-opioid receptors and limbic responses to aversive emotional stimuli. In: Proc Natl Acad Sci U S A. 99:2002;p. 7084–7089
- . In: Functional Cerebral SPECT and PET Imaging. Philadelphia, PA: Lippincott Williams & Wilkins; 2000;p. 45
- Imaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson's disease. J Nucl Med. 1998;39:1879–1884
- Simplified quantification and reproducibility studies of dopamine D2-receptor binding with iodine-123-IBF SPECT in healthy subjects. J Nucl Med. 1997;38:31–37
- . Functional brain imaging in pediatrics. Pediatr Clin North Am. 1992;39:777–799
- . Positron emission tomography in newborn infants. Clin Perinatol. 1991;18:549–562
- . Positron emission tomography study of human brain functional development. Ann Neurol. 1987;22:487–497
- . Maturational changes in cerebral function in infants determined by [18]FDG positron emission tomography. Science. 1986;231:840–843
- Development changes of cerebral blood flow and oxygen metabolism in children. Am J Neuroradiol. 1999;20:917–922
- . An adaptation of the nitrous oxide method to the study of the cerebral circulation in children: Normal values for cerebral blood flow and cerebral metabolic rate in childhood. J Clin Invest. 1957;36:1130
- Age-related changes in brain perfusion of normal subjects detected by 99mTc-HMPAO SPECT. Neuroradiology. 1998;40:428–434
- A semiquantitative cortical circumferential normalization method for clinical evaluation of rCBF brain SPECT. Clin Nucl Med. 1997;22:596–604
- Cerebral blood flow, blood volume, and oxygen utilization—Normal values and effects of age. Brain. 1990;113:27–47
- Effects of aging on the cerebral distribution of technetium-99m hexamethylpropylene amine oxime in healthy humans. Eur J Nucl Med. 1997;24:754–761
- 99mTc-d,1-HMPAO and SPECT of the brain in normal aging. J Cereb Blood Flow Metab. 1991;11:508–521
- Regional cerebral blood flow and oxygen consumption in human aging. Stroke. 1984;15:635–641
- Decreases in regional cerebral blood flow with normal aging. J Cereb Blood Flow Metab. 1991;11:684–689
- Age-related decline of cerebral oxygen metabolism in normal population detected with positron emission tomography. Neurol Res. 1992;14:128–131
- Regional cerebral blood flow as assessed by principal component analysis and (99m)Tc-HMPAO SPET in healthy subjects at rest: Normal distribution and effect of age and gender. Eur J Nucl Med Mol Imaging. 2002;29:67–75
- 99mTc-ECD brain perfusion SPET: Variability, asymmetry and effects of age and gender in healthy adults. Eur J Nucl Med. 2001;28:873–887
- Altered patterns of regional cerebral glucose metabolism in aging and dementia. J Cereb Blood Flow Metab. 1985;5:S121–S122
- Positron emission tomography studies of normal aging, a replication of PET III and 18-FDG using PET IV and II-CDG. Neurobiol Aging. 1987;8:319–323
- Positron emission tomography in aging and dementia. Effect of cerebral atrophy. J Nucl Med. 1987;28:431–437
- Effects of normal aging on whole brain and regional glucose metabolism as assessed by F-18 positron emission tomography. J Nucl Med. 1990;31:771
- Sensitivity of cerebral glucose metabolism to age, gender, brain volume, brain atrophy, and cerebrovascular risk factors. J Cereb Blood Flow Metab. 1988;8:654–661
- Effects of human aging on patterns of local cerebral glucose utilization determined by the 18-F fluorodeoxyglucose method. J Cereb Blood Flow Metab. 1982;2:163–171
- Anatomic and functional changes of the brain in normal aging and dementia as demonstrated by MRI, CT, and PET. Nucl Med Ann. 1989;49–79
- Regional cerebral function determined by FDG-PET in healthy volunteers: Normal patterns and changes with age. J Nucl Med. 1995;36:1141–1149
- Reduced temporal lobe glucose metabolism in aging. J Neuroimaging. 1995;5:178–182
- Determination of patterns of regional cerebral glucose metabolism in normal aging and dementia. J Nucl Med. 1985;26:P69
- Effects of gender on glucose utilization rates in healthy humans: A positron emission tomography study. J Neurosci Res. 1990;27:500–504
- Gender differences in cerebral glucose metabolism: A PET study. J Neurol Sci. 2002;199:79–83
- (suppl) The effect of normal aging on patterns of local cerebral glucose utilization. Ann Neurol. 1984;15:S133–S137
- Cerebral glucose metabolism as a function of age in man: Influence of the rate constants in fluorodeoxyglucose. J Cereb Blood Flow Metab. 1983;3:250–253
- . Cerebral blood flow and metabolism in normal human aging, pathological aging, and senile dementia. J Cereb Blood Flow Metab. 1985;5:1
- Reduction in regional cerebral metabolic rate of oxygen during human aging. Stroke. 1986;17:1220
- . Cerebral metabolism and blood flow in normal aging and pathological aging. In: Pagistretti PL editors. Functional Radionuclide Imaging of the Brain. New York, NY: Raven Press; 1983;
- The brain in healthy aged individuals. MR imaging. Radiology. 1990;174:675–679
- Cerebral structure on MRI, part I. Localization of age-related changes. Biol Psychiatry. 1991;29:55–67
- Analysis of brain and cerebrospinal fluid volumes with MR imaging. Impact on PET data, correction for atrophy. Radiology. 1991;178:123–130
- Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. In: Proc Natl Acad Sci U S A. 88:1991;p. 2845–2849
- Controlling for cerebral atrophy in positron emission tomography data. J Cereb Blood Flow Metab. 1987;7:510–512
- Relation of measured brain glucose utilization and cerebral atrophy in man. J Neurol Neurosurg Psychiatry. 1987;50:779–785
- The effect of focal cerebral atrophy in positron emission tomographic studies of aging and dementia. Nucl Med Biol. 1990;17:797–804
- . Age-dependent decline in human brain dopamine D1 and D2 response. Brain Res. 1990;508:349–352
- . Muscarinic and dopaminergic receptors in the aging human brain. Brain Res. 1987;404:162–168
- Divergent changes in D1 and D2 dopamine binding sites in human brain during aging. Neurobiol Aging. 1987;8:195–201
- Age-dependent decline of dopamine D1 receptors in human brain: A PET study. Synapse. 1998;30:56–61
- Age-dependent decline of nigrostriatal dopaminergic function: A positron emission tomographic study of grandparents and their grandchildren. Ann Neurol. 1994;36:667–670
- Positron emission tomography suggests that the rate of progression of idiopathic parkinsonism is slow. Ann Neurol. 1991;29:673–677
- Nigrostriatal function in man studied with positron emission tomography. Ann Neurol. 1989;26:535–542
- . Aging and extrapyramidal function. Arch Neurol. 1977;34:33–35
- . Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease. N Neurol Neurosurg Psychiatry. 1991;54:388–396
- Age-related reduction of extrastriatal dopamine D2 receptor measured by PET. Life Sci. 2001;69:1079–1084
- Age-related loss of extrastriatal dopamine D(2)-like receptors in women. J Neurochem. 2002;81:1005–1010
- Striatal function in normal aging: Implications for Parkinson's disease. Ann Neurol. 1990;28:799–804
- Striatal [18F]-DOPA uptake: Absence of an aging effect. J Cereb Blood Flow Metab. 1993;13:881–888
- Reproducibility of fluorine-18-6-fluorodopa positron emission tomography in normal human subjects. J Nucl Med. 1994;35:18–24
- Decrease in human striata dopamine D2 receptor density with age: A PET study with [11C] raclopride. J Cereb Blood Flow Metab. 1993;13:310–314
- Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol. Psychiatry Res. 1996;67:11–16
- . Dopamine D2 receptors in normal human brain: Effect of age measured by positron emission tomography (PET) and [11C] raclopride. Ann N Y Acad Sci. 1993;695:81–85
- Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain. Neurobiol Aging. 2000;21:683–688
- Age-related changes in human D1 dopamine receptors measured by positron emission tomography. Psychopharmacology. 1991;103:41–45
- Monoamine re-uptake sites in the human brain evaluated in vivo by means of [11C] nomifensine and positron emission tomography: The effects of age and Parkinson's disease. Acta Neurol Scand. 1988;77:192–201
- Age-related decline in striatal dopamine transporter binding with iodine-123-β-CIT SPECT. J Nucl Med. 1995;36:1175–1181
- 5-Hydroxytryptamine-sensitive 3H-imipramine binding of pro-tein nature in the human brain. II. Effect of normal aging and dementia disorders. Brain Res. 1987;425:137–145
- Effects of age on dopamine transporters in healthy humans. J Nucl Med. 1999;40:1812–1817
- Age-related decline of serotonin transporters in living human brain of healthy males. Life Sci. 2002;71:751–757
- Effects of ageing on serotonin transporters in healthy females. Eur J Nucl Med. 2001;28:911–913
- Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET. Neuropsychopharmacology. 2001;24:522–530
- Gender-specific aging effects on the serotonin 1A receptor. Brain Res. 2001;895:9–17
- 123I-5-I-R91150, a new single-photon emission tomography ligand for 5-HT2A receptors: Influence of age and gender in healthy subjects. Eur J Nucl Med. 1998;25:1617–1622
- Greater loss of 5-HT(2A) receptors in midlife than in late life. Am J Psychiatry. 2002;159:430–435
- Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: Persistence of effect after partial volume correction. Brain Res. 1998;813:167–171
- In vivo mapping of cholinergic terminals in normal aging, Alzheimer's disease, and Parkinson's disease. Ann Neurol. 1996;40:399–410
- Age-related changes in human muscarinic acetylcholine receptors measured by positron emission tomography. Neurosci Lett. 1993;149:225–228
- In vivo quantification of cerebral muscarinic receptors in normal human aging using positron emission tomography and [11C]tropanyl benzilate. J Cereb Blood Flow Metab. 1996;16:303–310
- Age-related decreases in muscarinic cholinergic receptor binding in the human brain measured with positron emission tomography (PET). J Neurosci Res. 1990;27:569–575
- Age-related increases in brain monoamine oxidase B in living healthy human subjects. Neurobiol Aging. 1997;18:431–435
- L-Methionine uptake by human cerebral cortex. Maturation from infancy to old age. J Nucl Med. 1991;32:16
- Assessment of [11C]-L-methionine transport into the human brain. J Cerebr Blood Flow Metab. 1988;8:341–345
- Use of [11C] aminocyclohexane-carboxylate for the measurement of amino acid uptake and distribution volume in human brain. J Cerebr Blood Flow Metab. 1990;10:727–739
- Aging effect on neutral amino acid transport at the blood-brain barrier measured with L-[2-18F]-Fluorophenylalanine and PET. J Nucl Med. 1995;35:1232–1237
PII: S0001-2998(03)80005-3
doi:10.1053/snuc.2003.127292
© 2003 Published by Elsevier Inc.
