Seminars in Nuclear Medicine
Volume 36, Issue 2 , Pages 133-146 , April 2006

The Role of Nuclear Medicine in the Detection of Acute Gastrointestinal Bleeding

  • Douglas M. Howarth (FRACP)

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Douglas Howarth, FRACP, PO Box 744, Warners Bay, NSW 2282, Australia.

References 

  1. Bibi EJ , Rajapaska RC , Valdes MT , et al.   Is upper gastrointestinal endoscopy indicated in asymptomatic patients with a positive fecal occult blood test and negative colonoscopy? . Am J Med . 1999;106:613–618
  2. Strate LL , Syngal S . Predictors of utilization of early colonoscopy vs radiography for severe lower intestinal bleeding . Gastro Endoscopy . 2005;61:47–52
  3. Schrock TR . Colonoscopic diagnosis and treatment of lower gastrointestinal bleeding . Surg Clin North Am . 1989;69:1309–1325
  4. Nusbaum M , Baum S . Radiographic demonstration of unknown site of gastrointestinal bleeding . Surg Forum . 1963;14:374–375
  5. Athanasoulis CA , Waltman AC , Novelline RA , et al.   Angiography (its contribution to the emergency management of gastrointestinal hemorrhage) . Radiol Clin North Am . 1976;14:265–280
  6. Best EB , Teaford KA , Rader FH . Angiography in chronic recurrent gastrointestinal bleeding (a nine year study) . Surg Clin North Am . 1979;59:811–829
  7. Guy GE , Shetty PC , Sharma RP , et al.   Acute lower gastrointestinal hemorrhage treatment by superselective embolization with polyvinyl alcohol particles . Am J Roentgenol . 1992;159:521–526
  8. Parkes BM , Obeid FN , Sorensen VJ , et al.   The management of lower gastrointestinal bleeding . Am Surg . 1993;59:676–678
  9. Al Oahtani FR , Satin R , Stern J , et al.   Investigative modalities for massive lower gastrointestinal bleeding . World J Surg . 2002;26:620–625
  10. Gostout CJ . Acute gastrointestinal bleeding—a common problem revisited . Mayo Clin Proc . 1988;63:596–604
  11. Maurer AH . Gastrointestinal bleeding and cine-scintigraphy . Semin Nucl Med . 1996;26:43–50
  12. Mullan BP . Gastrointestinal system . In:  O’Connor MK editors. The Mayo Clinic Manual of Nuclear Medicine . New York: Churchill Livingstone; 1996;p. 329–332
  13. McKusick KA , Froelich J , Callahan RJ , et al.   99mTc red blood cells for detection of gastrointestinal bleeding (Experience with 80 patients) . AJR . 1981;137:1113–1118
  14. Winzelberg GG , Froelich JW , McKusick KA , et al.   Scintigraphic detection of gastrointestinal bleeding (a review of current methods) . Am J Gastroenterol . 1983;78:324–327
  15. Gunderman R , Leef J , Ong K , et al.   Scintigraphic screening prior to visceral arteriography in acute lower gastrointestinal bleeding . J Nucl Med . 1998;39:1081–1083
  16. Royal HD . In:  Coleman E ,  Balufox MD ,  Royal HD , et al. editor. Year Book of Nuclear Medicine 2004 . St. Louis: Mosby; 2004;p. 113–114
  17. Winzelberg GG , McKusick KA , Strauss HW , et al.   Evaluation of gastrointestinal bleeding by red blood cells labelled in vivo with technetium-99m . J Nucl Med . 1979;20:1080–1086
  18. Thorne DA , Datz FL , Remley K , Christian PE . Bleeding rates necessary for detecting acute gastrointestinal bleeding with technetium-99m-labeled red blood cells in an experimental model . J Nucl Med . 1987;28:514–520
  19. Smith RK , Arterburn G . Detection and localization of gastrointestinal bleeding using Tc-99m-pyrophosphate in vivo labelled red blood cells . Clin Nucl Med . 1980;5:57–60
  20. Miskowiak J , Nielsen SL , Munck O , et al.   Abdominal scintiphotography with Tc99m technetium labelled albumin in acute gastrointestinal bleeding . Lancet . 1977;2:852–854
  21. Alavi A , Dann RW , Baum S , et al.   Scintigraphic detection of acute gastrointestinal bleeding . Radiology . 1977;124:753–756
  22. Alavi A , Ring EJ . Localization of gastrointestinal bleeding (superiority of Tc-99m sulfur colloid compared with angiography) . AJR Am J Roentgenol . 1981;137:741–748
  23. Ponzo F , Zhuang HM , Liu FM , et al.   Tc-99m sulfur colloid and Tc-99m tagged red blood cell methods are comparable for detecting lower gastrointestinal bleeding in clinical practice . Clin Nucl Med . 2002;27:405–409
  24. Miskowiak J , Nielson SL , Munck O . Scintigraphic diagnosis of gastrointestinal bleeding with Tc-99m labelled blood pool agents . Radiology . 1981;141:499–504
  25. Som P , Oster ZH , Atkins HL , et al.   Detection of gastrointestinal blood loss with Tc-99m-labeled heat-treated red blood cells . Radiology . 1981;138:207–209
  26. Winzelberg GG . Detection of intermittent gastrointestinal bleeding with indium 111 labeled erythrocytes . J Nucl Med . 1981;22:96–97
  27. Mole DJ , Hughes SJ , Khosraviani K . 111-indium-labeled red-cell scintigraphy to detect intermittent gastrointestinal bleeding from synchronous small and large bowel adenocarcinomas . Eur J Gastroenterol Hepatol . 2004;16:795–799
  28. Ferrant A , Dehasque N , Leners N , et al.   Scintigraphy with In-111-labeled red cells in intermittent gastrointestinal bleeding . J Nucl Med . 1980;21:844–845
  29. Habibian RM , Tedeschi AA . Imaging of the gastrointestinal tract . In:  Sandler MP ,  Patton JA ,  Shaff MI , et al. editor. Correlative Imaging . Baltimore: Williams and Wilkins; 1989;p. 450–477
  30. Turgeon DK , Bennet JL . Meckel’s diverticulum . Am J Gastroenterol . 1990;85:777–781
  31. Maurer AH . Gastrointestinal bleeding . In:  Ell PJ ,  Gambhir GG editor. Nuclear Medicine in Clinical Diagnosis and Treatment . (ed 3).. Sydney: Churchill Livingstone; 2004;p. 911–917
  32. Brayton D . Gastrointestinal bleeding of unknown origin . Am J Dis Child . 1964;107:288–292
  33. Kong MS , Huang SC , Tzen KY , et al.   Repeated technetium-99m pertechnetate scanning for children with obscure gastrointestinal bleeding . J Pediatr Gastroenterol Nutr . 1994;18:284–287
  34. Swaniker F , Soldes O , Hirschl RB . The utility of technetium-99m pertechnetate scintigraphy in the evaluation of patients with Meckel’s diverticulum . J Pediatr Surg . 1999;34:760–765
  35. Sfakianakis CN , Conway JJ . Detection of ectopic gastric mucosa in Meckel’s diverticulum and in other aberrations of scintigraphy: I: pathophysiology and 10 year clinical experience . J Nucl Med . 1981;22:647–654
  36. Sfakianakis GN , Conway JJ . Detection of ectopic gastric mucosa in Meckel’s diverticulum and in other aberrations by scintigraphy: II: indications and methods- a 10 year experience . J Nucl Med . 1981;22:732–738
  37. Sfakianakis GN , Haase GM . Abdominal scintigraphy for ectopic gastric mucosa (a retrospective analysis of 143 studies) . AJR Am J Roentgenol . 1982;138:7–12
  38. Kong MS , Chen CY , Tzen KY , et al.   Technetium-99m pertechnetate scan for ectopic gastric mucosa in children with gastrointestinal bleeding . J Formos Med Assoc . 1993;92:717–720
  39. Fries M , Mortensson W , Robertson B . Technetium pertechnetate scintigraphy to detect ectopic gastric mucosa in Meckel’s diverticulum . Acta Radiol Diag . 1984;25:417–422
  40. Schwartz JS , Lewis JH . Meckel’s diverticulum (pitfalls in scintigraphic detection in the adult) . Am J Gastroenterol . 1984;79:611–618
  41. Treves S , Grand RJ , Eraklis AJ . Pentagastrin stimulation of technetium 99m uptake by ectopic gastric mucosa in a Meckel’s diverticulum . Radiology . 1978;128:711–712
  42. Datz FL , Christian PE , Hutson WR , et al.   Physiological and pharmacological interventions in radionuclide imaging of the tubular gastrointestinal tract . Semin Nucl Med . 1991;22:140–152
  43. Petrokubi RJ , Baum S , Rohrer GV . Cimetidine administration resulting in improved pertechnetate imaging of Meckel’s diverticulum . Clin Nucl Med . 1978;3:385–388
  44. Brown ML . Gastrointestinal bleeding . In:  Wagner HN ,  Szabo Z ,  Buchanan JW editor. Principles of Nuclear Medicine . (ed 2).. Philadelphia: WB Saunders Company; 1995;p. 929–934
  45. Kalff V , Kelly MJ , Dudley F , et al.   Abdominal blood pool scintigraphy in the management of acute or intermittent gastrointestinal bleeding . Med J Aust . 1983;2:326–334
  46. Diamond RH , Rothstein RD , Alavi A . The role of cimetidine enhanced technetium-99m-pertechnetate imaging for visualizing Meckel’s diverticulum . J Nucl Med . 1991;32:1422–1424
  47. Yen CK , Lanoie Y . Effect of stannous pyrophosphate red blood cell gastrointestinal bleeding scan on subsequent Meckel’s scan . Clin Nucl Med . 1991;17:454–456
  48. Heyman MK , Sunaryo FP , Ziegler MM . Gastrointestinal bleeding (an accessory spleen causing a false-positive Tc-99m sulfur colloid study) . Clin Nucl Med . 1982;7:38–40
  49. Champagne C , Powe JE . Incidental detection of ruptured spleen during Tc-99m RBC gastrointestinal bleeding study . Clin Nucl Med . 1992;17:404–405
  50. Amster JL , Cohen AJ . Splenic hemorrhage demonstrated on Tc-99m-sulfur colloid spleen scan . Clin Nucl Med . 1983;8:269
  51. Swayne LC , Schroeder DC , Peterson DP . CAPD catheter site uptake during RBC gastrointestinal bleeding scan . Clin Nucl Med . 1991;16:936–937
  52. Moreno AJ , Reeves TA , Pearson VD , et al.   Unusual manifestations of hemorrhage during technetium-99m red cell blood pool imaging . Clin Nucl Med . 1989;14:470–471
  53. Gips S , Israel O . Scintigraphic detection of bleeding after transfemoral arteriography, using technetium-99m labelled RBCs . Clin Nucl Med . 1986;11:669
  54. Shah GK , Stoler BB , Rovere J . Demonstration of bleeding site by Tc-99m labeled red cells . Radiology . 1979;132:169–170
  55. Kahn D , Wilson DG . Clinically significant bleeding in breast tissue identified by erythrocyte scintigraphy . Clin Nucl Med . 1987;12:973
  56. Fink-Bennett DM , Johnson JR . Gluteal hematoma (a potential cause of false positive Tc-99m RBC gastrointestinal bleeding study) . Clin Nucl Med . 1984;9:414
  57. Gonzalez CE , Fig LM , Cano M , et al.   Technetium-99m red blood cell scintigraphy in localization of non-enteric hemorrhage . J Nucl Med . 1994;35:1333–1337
  58. Rosenbaum RC , Johnson GS , Whitley NO . Scintigraphic detection of occult hemorrhage in a patient receiving anticoagulants . J Nucl Med . 1986;27:223–225
  59. Orzel JA , Rudd TG , Oreskovich M . Evaluation of traumatic mesenteric hemorrhage in a hemophiliac with 99m-technetium-labeled red blood cell scintigraphy . J Trauma . 1986;26:1056–1057
  60. Green D , Spies SM , Rana NA , et al.   Hemophilic bleeding evaluated by blood pool scanning . Thromb Haemost . 1981;45:208–210
  61. Bunker SR , Kolina JS , Kaplan KA , et al.   Scintigraphic detection of occult hemorrhage using RBCs labeled in vitro with technetium-99m-sodium pertechnetate . Arch Intern Med . 1983;143:1027–1028
  62. Moreno AJ , Byrd BF , Berger DE , et al.   Abdominal varices mimicking an acute gastrointestinal hemorrhage during technetium-99m red blood scintigraphy . Clin Nucl Med . 1985;10:248–251
  63. Karimeddini MK , Dambro TJ , Gabor MP , et al.   Omental varices detected on a radionuclide gastrointestinal bleeding study . Clin Nucl Med . 1992;17:672–673
  64. Ben-Haim S , Rezai K . Intraperitoneal bleeding demonstrated by Tc-99m labeled red blood cell scintigraphy . Clin Nucl Med . 1992;17:789–790
  65. Ellison MJ , Thornberg A , Turbiner E . Demonstration of bleeding into a pancreatic pseudocyst on a technetium 99m labeled red blood cell scan . Clin Nucl Med . 1987;12:969
  66. Anez LF , Gupta SM . Serindipidous detection of a horseshoe kidney during blood imaging for gastrointestinal bleeding . Clin Nucl Med . 1992;17:132–133
  67. Camele RA , Bansal SK , Turbiner EH . Red blood cell gastrointestinal bleeding scintigraphy. Appearance of the left ovarian vein . Clin Nucl Med . 1984;9:275–276
  68. Zukier LS , Patel YD . Incidental abnormalities detected during scintigraphy for gastrointestinal bleeding . Radiographics . 1990;10:467–481
  69. Oskin JE , Alexander JM , Bekerman C , et al.   Alterations of the dynamics in the arterial mesenteric circulation secondary to atherosclerosis—a new pitfall of GI bleeding studies with Tc-99m tagged RBCs . Clin Nucl Med . 1991;16:524–525
  70. Lecklitner ML , Hughes JJ . Pitfalls of gastrointestinal bleeding studies with Tc-99m labeled RBCs . Semin Nucl Med . 1986;16:151–154
  71. Goergen TG . Serendipity in scintigraphic gastrointestinal bleeding studies . Clin Nucl Med . 1983;8:396–399
  72. Bunko H , Seto H , Tonami N , et al.   Detection of active bleeding from ruptured aorta aneurysm by emergency radionuclide angiography . Clin Nucl Med . 1978;3:276–277
  73. Brill DR . Gallbladder visualization during technetium-99m labeled red cell scintigraphy for gastrointestinal bleeding . J Nucl Med . 1985;26:1408–1411
  74. Vidal-Sicart S , Lomena F , Setoain FJ , et al.   Gallbladder visualization on RBC scintigraphy . Clin Nucl Med 1996 . 1996;21:660
  75. Wood MJ , Hennigan DB . Radionuclide tagged red blood cells in the gall bladder . Clin Nucl Med . 1984;9:289–290
  76. Sato S , Kuwajima A , Watanabe S , et al.   Delayed visualization of gallbladder with in vivo labeled Tc-99m red blood cell scintigraphy for gastrointestinal bleeding . Radiat Med . 1988;6:159–161
  77. Abello R , Haynie TP , Kim EE . Pitfalls of a Tc-99m RBC bleeding study due to gallbladder and ileal-loop visualization . Gastrointest Radiol . 1991;16:32–34
  78. Howarth DM , Davidson P . Neonatal gastric hemorrhage showing gallbladder visualization with Tc-99m red blood cell scintigraphy . Clin Nucl Med . 2002;27:524–526
  79. Miskowiak J , Pedersen JH , Siemssen OJ , et al.   Hemobilia in haemochromatosis localized by 99m-technetium-albumin scintigraphy . Acta Chir Scand . 1979;145:125–127
  80. Sun SS , Hsieh JF , Tsai SC , et al.   Unexpected detection of colon lymphoma on a Tc-99m labeled red blood cell abdominal scan . Clin Nucl Med . 2000;25:1052–1053
  81. Sanli Y , Adalet I , Turkmen C , et al.   Primary lymphoma of the small bowel detected with red blood cell scintigraphy . Clin Nucl Med . 2005;30:490–491
  82. Gordon BM , Herlong J , Uflacker R , et al.   Recurrent lower gastrointestinal hemorrhage (Ileal neoplasm diagnosed by scintigraphy with Tc-99m red blood cells and angiography) . South Med J . 1996;89:1204–1207
  83. Meller J , Schonborn E , Conrad M , et al.   Improved demonstration of gastrointestinal bleeding sites by means of Tc-99m-labeled autologous erythrocytes and continuous dynamic scintigraphy . Churg . 2000;71:292–299
  84. O’Neill BB , Gosnell JE , Lull RJ , et al.   Cinematic nuclear scintigraphy reliably directs surgical intervention for patients with gastrointestinal bleeding . Arch Surg . 2000;135:1076–1082
  85. Maurer AH , Rodman MS , Vitti RA , et al.   Gastrointestinal bleeding (Improved localization with cine scintigraphy) . Radiology . 1992;185:187–192
  86. Bunker SR . Cine scintigraphy for gastrointestinal bleeding . Radiology . 1993;877–878
  87. Schmulewitz N , Fisher DA , Rockey DC . Early colonoscopy for acute lower GI bleeding predicts shorter hospital stay (a retrospective study of experience in a single center) . Gastro Endoscopy . 2003;6:841–846
  88. Gostout CJ . Acute gastrointestinal bleeding—a common problem revisited . Mayo Clin Proc . 1988;63:596–604
  89. Kollef MH , O’Brien JD , Zuckerman GR , et al.   BLEED (a classification tool to predict outcomes in patients with acute upper and lower gastrointestinal hemorrhage) . Crit Care Med . 1997;25:1125–1132
  90. Feingold DL , Caliendo FJ , Chinn BT , et al.   Does hemodynamic instability predict positive technetium-labeled red blood cell scintigraphy in patients with acute lower gastrointestinal bleeding? A review of 50 patients . Dis Colon Rectum . 2005;48:1001–1004
  91. Velayos FS , Williamson A , Sousa KH , et al.   Early predictors of severe lower gastrointestinal bleeding and adverse outcomes (a prospective study) . Clin Gastroentol Hepatol . 2004;2:485–490
  92. Smith R , Copely DJ , Bolen FH . 99m-Tc RBC Scintigraphy (correlation of gastrointestinal bleeding rates with scintigraphic findings) . AJR Am J Roentgenol . 1987;148:869–874
  93. Olds GD , Cooper GS , Chak A , et al.   The yield of bleeding scans in acute lower gastrointestinal hemorrhage . J Clin Gastroenterol . 2005;39:273–277
  94. Levy R , Barto W , Gani J . Retrospective study of the utility of nuclear scintigraphic-labelled red cell scanning for lower gastrointestinal bleeding . ANZ J Surg . 2003;73:205–209
  95. Kourakis G , Misiakos E , Koratzas G , et al.   Diagnostic approach and management of active lower gastrointestinal hemorrhage . Int Surg . 1995;80:138–140
  96. Hunter JM , Pezim ME . Limited value of technetium 99m-labeled red cell scintigraphy in localization of lower gastrointestinal bleeding . Am J Surg . 1990;159:504–506
  97. Suzman MS , Talmor M , Jennis R , et al.   Accurate localization and surgical management of active lower gastrointestinal hemorrhage with technetium-labeled erythrocyte scintigraphy . Ann Surg . 1996;224:29–36
  98. Nicholson ML , Neoptolemos JP , Sharp JF , et al.   Localization of lower gastrointestinal bleeding using in vivo technetium-99m-labelled red blood cell scintigraphy . Br J Surg . 1989;76:358–361
  99. Bentley DE , Richardson JD . The role of tagged red blood cell imaging in the localization of gastrointestinal bleeding . Arch Surg . 1991;126:821–824
  100. Dusold R , Burke K , Carpentier W , et al.   The accuracy of technetium-99m-labeled red cell scintigraphy in localizing gastrointestinal bleeding . Am J Gastroenterol . 1994;89:345–348
  101. Gutierrez C , Mariano M , Vander Laan T , et al.   The use of technetium-labeled erythrocyte scintigraphy in the evaluation and treatment of lower gastrointestinal hemorrhage . Am Surg . 1998;64:989–992
  102. Ryan P , Styles CB , Chmiel R . Identification of the site of severe colonic bleeding by technetium-labeled red-cell scan . Dis Colon Rectum . 1992;35:219–222
  103. Pennoyer WP , Vignati PV , Cohen JL . Mesenteric angiography for lower gastrointestinal hemorrhage. Are there predictors for a positive study? . Dis Colon Rectum . 1997;40:1014–1018
  104. Orecchia PM , Hensley EK , McDonald PT , et al.   Localization of lower gastrointestinal hemorrhage (experience with red blood cells labelled in vitro with technetium Tc-99m) . Arch Surg . 1985;120:621–624
  105. Winzelberg GG , Froelich JW , McKusick KA , et al.   Radionuclide localization of lower gastrointestinal hemorrhage . Radiology . 1981;139:465–469
  106. Bunker SR , Lull RJ , Tanasescu DE , et al.   Scintigraphy of gastrointestinal hemorrhage (superiority of Tc-99m red blood cells over Tc-99m sulfur colloid) . AJR Am J Roentgenol . 1984;143:543–548
  107. Ohri SK , Desa LA , Lee H , et al.   Value of scintigraphic localization of obscure gastrointestinal bleeding . J R Coll Surg Edinb . 1992;37:328–332
  108. Vernava AM , Moore BA , Longo WE , et al.   Lower gastrointestinal bleeding . Dis Colon Rectum . 1997;40:846–858
  109. Wu Y , Seto H . Clinical value of sequential subtraction scintigraphy with 99m-Tc-RBC for gastrointestinal bleeding . Chin Med J . 2001;114:69–72
  110. Rantis PC , Harford FJ , Wagner RH , et al.   Technetium-labelled red blood cell scintigraphy (is it useful in acute lower gastrointestinal bleeding?) . Int J Colorect Dis . 1995;10:210–215
  111. Weis M , Heidenreich P , Von Finckenstein W , et al.   Clinical value of scintigraphy in gastrointestinal bleeding (results in a large community hospital) . Dtsch Med Wschr . 2000;125:383–390
  112. Gupta S , Luna E , Kingsley S , et al.   Detection of gastrointestinal bleeding by radionuclide scintigraphy . Am J Gastroenterol . 1984;79:26–31
  113. Szasz IJ , Morrison RT , Lyster DM . Technetium-99m-labelled red blood cell scaning to diagnose occult gastrointestinal bleeding . Can J Surg . 1985;28:512–514
  114. Voeller GR , Bunch G , Britt LG . Use of technetium-labeled red blood cell scintigraphy in the detection and management of gastrointestinal hemorrhage . Surgery . 1991;110:799–804
  115. Markisz JA , Front D , Royal HD , et al.   An evaluation of Tc-99m-labeled red blood cell scintigraphy for the detection and localization of gastrointestinal bleeding sites . Gastroenterology . 1982;83:394–398
  116. Moncure AC , Tompkins RG , Athanasoulis CA , et al.   Occult gastrointestinal bleeding (newer techniques of diagnosis and therapy) . Adv Surg . 1989;22:141–178
  117. Eckstein MR , Athanasoulis CA . Gastrointestinal bleeding, an angiographic perpective . Surg Clin North Am . 1984;64:37–50
  118. Gunderman R , Leef J , Ong K , et al.   Scintigraphic screening prior to visceral arteriography in acute lower gastrointestinal bleeding . J Nucl Med . 1998;39:1081–1083
  119. Ng DA , Opelka FG , Beck DE . Predictive value of technetium-99m labelled red blood cell scintigraphy for positive angiogram in massive lower gastrointestinal hemorrhage . Dis Colon Rectum . 1997;40:471–477
  120. Zettinig G , Staudenherz A , Leitha T . The importance of delayed images in gastrointestinal bleeding scintigraphy . Nuc Med Commun . 2002;23:803–808
  121. Jacobson AF . Delayed positive gastrointestinal bleeding studies with technetium-99m red blood cells (utility of a second injection) . J Nucl Med . 1991;32:330–332
  122. Howarth DM , Tang K , Lees W . The clinical utility of nuclear medicine imaging for the detection of occult gastrointestinal haemorrhage . Nucl Med Commun . 2002;23:591–594
  123. Kan JH , Funaki B , O’Rourke BD , et al.   Delayed 99mTc-labeled erythrocyte scintigraphy in patients with lower gastrointestinal tract hemorrhage . Acad Radiol . 2003;10:497–501
  124. O’Brien PC , Shampo MA , Robertson JS . Statistics for nuclear medicine, part 3: A: Comparing two proportions (the relative deviate test and chi-square equivalent). B: counting data . J Nucl Med . 1983;24:269–272
  125. Jacobson AF , Cerqueira MD . Prognostic significance of late imaging results in technetium-99m-labeled red blood cell gastrointestinal bleeding studies with early negative images . J Nucl Med . 1992;33:202–207
  126. Friedman HI , Hilts SV , Whitney PJ . Use of technetium-labeled autologous red blood cells in detection of gastrointestinal bleeding . Surg Gynecol Obstet . 1983;156:449–452
  127. Van Geelen JA , De Graaf EM , Bronsveld W , et al.   Clinical value of labeled red blood cell scintigraphy in patients with difficult to diagnose gastrointestinal bleeding . Clin Nucl Med . 1994;19:949–952
  128. Robinson P . The role of nuclear medicine in acute gastrointestinal bleeding . Nucl Med Commun . 1993;14:849–855
  129. Ford PV , Bartold SP , Fink-Bennett DM , et al.  Society of Nuclear Medicine   Procedure guidelines for gastrointestinal bleeding and Meckel’s diverticulum scintigraphy . J Nucl Med . 1999;40:1226–1232
  130. Vernava AM , Moore BA , Longo WE , et al.   Lower gastrointestinal bleeding . Dis Colon Rectum . 1997;40:846–858

PII: S0001-2998(05)00068-1

doi: 10.1053/j.semnuclmed.2005.11.001

Seminars in Nuclear Medicine
Volume 36, Issue 2 , Pages 133-146 , April 2006

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