Seminars in Nuclear Medicine
Volume 36, Issue 3 , Pages 206-211 , July 2006

Parathyroid Imaging: How Good Is It and How Should It Be Done?

  • Andrew G. Kettle, BA
  • ,
  • Mike J. O’Doherty, MBBS, MSc, MD, FRCP

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Mike O’Doherty, MBBS, MSc, MD, FRCP, Department of Nuclear Medicine, East Kent Hospitals NHS Trust, Kent & Canterbury Hospital, Canterbury, Kent, United Kingdom

References 

  1. Bilezikian JP , Potts JT , Fuleihan Gel-H , et al.   Summary statement from a workshop on asymptomatic primary hyperparathyroidism (a perspective for the 21st century) . J Clin Endocrinol Metab . 2002;87:5353–5361
  2. Thomas SK , Wishart GC . Trends in surgical techniques . Nucl Med Commun . 2003;24:115–119
  3. Edis AJ , Sheedy PF , Beahrs OH , et al.   Results of re-operation for hyperparathyroidism, with evaluation of pre-operative localisation studies . Surgery . 1978;84:384–393
  4. Ruda JM , Hollenbeak CS , Stack BC . A systematic review of the diagnosis and treatment of primary hyperparathyroidism from 1995 to 2003 . Otolaryngol Head Neck Surg . 2005;132:359–372
  5. O’Doherty MJ , Kettle AG . Parathyroid imaging (preoperative localization) . Nucl Med Commun . 2003;24:125–131
  6. Ferlin G , Borsato N , Camerani M , et al.   New perspectives in localising enlarged parathyroids by technetium-thallium subtraction scan . J Nucl Med . 1983;24:438–441
  7. Sandrock D , Dunham RG , Neumann RD . Simultaneous dual energy acquisition for 20lTl/99mTc parathyroid subtraction scintigraphy (physical and physiological considerations) . Nucl Med Commun . 1990;11:503–510
  8. Coakley AJ , Kettle AG , Wells CP , et al.   99mTc-sestamibi new agent for parathyroid imaging . Nucl Med Commun . 1989;10:791–794
  9. O’Doherty MJ , Kettle AG , Wells PC , et al.   Parathyroid imaging with technetium-99m-sestamibi (preoperative localisation and tissue uptake studies) . J Nucl Med . 1992;33:313–318
  10. Fjeld JG , Erichson K , Pfeffer PF , et al.   Tc-99m-tetrofosmin for parathyroid imaging (comparison with sestamibi) . J Nucl Med . 1997;38:831–834
  11. Giordano A , Meduri G , Marozzi P . Parathyroid imaging with 99mTc-tetrofosmin . Nucl Med Comm . 1996;17:706–710
  12. Froberg AC , Valkema R , Bonjer HJ , et al.   99m Technetium-tetrofosmin or 99mtechnetium-sestamibi for double-phase parathyroid scintigraphy . Eur J Nucl Med Mol Imaging . 2003;30:193–196
  13. Neumann DR , Esselstyn CB , MacIntyre WJ , et al.   Primary hyperparathyroidism (preoperative parathyroid imaging with regional body FDG PET) . Radiology . 1994;192:509–512
  14. Melon P , Luxen A , Hamoir E , et al.   Fluorine-18-fluorodeoxyglucose positron emission tomography for pre-operative parathyroid imaging in primary hyperparathyroidism . Eur J Nucl Med . 1995;22:556–558
  15. Beggs AD , Hain SF . Localization of parathyroid adenomas using 11C-Methionine positron emission tomography . Nucl Med Commun . 2005;26:133–136
  16. Sundin A , Johansson C , Hellman P , et al.   PET and parathyroid l-[carbon-11] methionine accumulation in hyperparathyroidism . J Nucl Med . 1996;37:1766–1770
  17. De Feo ML , Colagrande S , Biagini C , et al.   Parathyroid glands (combination of 99mTc MIBI scintigraphy US for demonstration of parathyroid glands nodules) . Radiology . 2000;214:393–402
  18. Casara D , Rubello D , Pelizzo MR , et al.   Clinical role of 99mTcO4/MIBI scan, ultrasound and intraoperative gamma probe in the performance of unilateral and minimally invasive surgery in primary hyperparathyroidism . Eur J Nucl Med . 2001;28:1351–1359
  19. Ammori BJ , Madan M , Gopichandran TD , et al.   Ultrasound-guided unilateral neck exploration for sporadic primary hyperparathyroidism (is it worthwhile?) . Ann R Coll Surg Engl . 1998;80:433–437
  20. Lumachi F , Ermani M , Basso S , et al.   Localization of parathyroid tumours in the minimally invasive era (which technique should be chosen? Population-based analysis of 253 patients undergoing parathyroidectomy and factors affecting parathyroid gland detection) . Endocrine-Related Cancer . 2001;8:63–69
  21. Stark DD , Gooding GAW , Moss AA , et al.   Parathyroid imaging (comparison of high-resolution CT and high-resolution sonography) . AJR Am J Roentgenol . 1983;141:633–638
  22. Dijkstra B , Healy C , Kelly LM , et al.   Parathyroid localisation–current practice . J R Coll Surg Edinb . 2002;47:599–607
  23. Miller DL , Doppman JL , Krudy AG , et al.   Localisation of parathyroid adenomas in patients who have undergone surgery. Part 1. Non-invasive imaging methods . Radiology . 1987;162:133–137
  24. Delbridge LW , Dolan SJ , Hop TT , et al.   Minimally invasive parathyroidectomy (50 consecutive cases) . Med J Aust . 2000;172:418–422
  25. Solorzano CC , Carneiro-Pla DM , Irvin GL . Surgeon-performed ultrasonography as the initial and only localizing study in sporadic primary hyperparathyroidism . J Am Coll Surg . 2006;202:18–24
  26. Milas M , Stephen A , Berber E , et al.   Ultrasonography for the endocrine surgeon (A valuable clinical tool that enhances diagnostic and therapeutic outcomes) . Surgery . 2005;138:1193–1201
  27. Pons F , Torregrosa JV , Fuster D . Biological factors influencing parathyroid localization . Nucl Med Commun . 2003;24:121–124
  28. Torregrosa J-V , Fernandez-Cruz L , Canalejo A , et al.   2000 99mTc-sestamibi scintigraphy and cell cycle in parathyroid glands of secondary hyperparathyroidism . World J Surg . 2000;24:1386–1390
  29. Taillefer R , Boucher Y , Potviuc C , et al.   Detection and localisation of parathyroid adenomas in patients with hyperparathyroidism using a single radionuclide imaging procedure with 99mTc sestamibi (double phase study) . J Nucl Med . 1992;33:1801–1807
  30. Arveschoug AK , Bertelsen H , Vammen B . Presurgical localization of abnormal parathyroid glands using a single injection of Tc-99m sestamibi comparison of high resolution parallel hole and pinhole collimators, and interobserver and intraobserver variation . Clin Nucl Med . 2002;27:249–254
  31. Ho Shon IA , Bernard EJ , Roach PJ , et al.   The value of oblique pinhole images in pre-operative localisation with 99mTc-MIBI for primary hyperparathyroidism . Eur J Nucl Med . 2001;28:736–742
  32. Wanet PM , Sand A , Abramovici J . Physical and clinical evaluation of high-resolution thyroid pinhole tomography . J Nucl Med . 1996;37:2017–2020
  33. Hindie E , Melliere D , Jeanguillame C , et al.   Parathyroid imaging using simultaneous double window recording of technetium-99m-sestamibi and iodine-123 . J Nucl Med . 1998;39:1100–1105
  34. Gayed IW , Kim EE , Broussard WF , et al.   The value of 99mTc-sestamibi SPECT/CT over conventional SPECT in the evaluation of parathyroid adenomas or hyperplasia . J Nucl Med . 2005;46:248–252
  35. Palazzo FF , Sadler GP , Reene TS . Minimally invasive parathyroidectomy . BMJ . 2004;328:849–850
  36. Rubello D , Pelizzo MR , Boni G , et al.   Radioguided surgery of primary hyperparathyroidism using low-dose 99mTc sestamibi protocol (multiinstitutional experience from the Italian study group on radioguided surgery and immunoscintigraphy (GISCRIS)) . J Nucl Med . 2005;46:220–226
  37. Neumann DR , Esselstyn CB , Go RT , et al.   Comparison of double-phase 99m Tc-sestamibi with 123I-99mTc-sestamibi subtraction SPECT in hyperparathyroidism . AJR Am J Roentgenol . 1997;169:1671–1674
  38. Leslie WD , Dupont JO , Bybel B , et al.   Parathyroid 99mTc-sestamibi scintigraphy (Dual-tracer subtraction is superior to double-phase washout) . Eur J Nucl Med Mol Imaging . 2002;2002 29:1566–1570
  39. Chen CC , Holder LE , Scovill WA , et al.   Comparison of parathyroid imaging with Tc-99m pertechnetate/sestamibi subtraction, double phase Tc-99m sestamibi and Tc-99m sestamibi SPECT . J Nucl Med . 1997;38:834–839
  40. Spanu A , Falchi A , Manca A , et al.   The usefulness of neck pinhole SPECT as a complementary tool to planar scintigraphy in primary and secondary hyperparathyroidism . J Nucl Med . 2004;45:40–48
  41. Udelsman R . Six hundred fifty-six consecutive explorations for primary hyperparathyroidism . Ann Surg . 2002;235:665–670

PII: S0001-2998(06)00016-X

doi: 10.1053/j.semnuclmed.2006.03.003

Seminars in Nuclear Medicine
Volume 36, Issue 3 , Pages 206-211 , July 2006