Seminars in Nuclear Medicine
Volume 37, Issue 4 , Pages 261-268 , July 2007

Renal Infection and Vesico-Ureteric Reflux

  • Monica A. Rossleigh, MBBS (Hons), MD, FRACP

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Monica A. Rossleigh, MBBS (Hons), MD, FRACP, Department of Nuclear Medicine, Prince of Wales and Sydney Children’s Hospital, Barker Street, Randwick, NSW 2031, Australia.

References 

  1. Fidler K, Hyer W. A strategy for UTI in children. Practitioner. 1998;242:538–541
  2. Hellström A, Hanson E, Hansson S, et al. Association between urinary symptoms at 7 years old and previous urinary tract infection. Arch Dis Child. 1991;66:232–234
  3. Koff SA. A practical approach to evaluating urinary tract infection in children. Paediatr Nephrol. 1991;5:398–400
  4. Haycock GB. A practical approach to evaluating urinary tract infection in children. Paediatr Nephrol. 1991;5:401–402
  5. Report of a Working Group of the Research Unit, Royal College of Physicians: Guidelines for the management of urinary tract infection in childhood. J R Coll Phys Lond. 1991;25:36–42
  6. Stark H. Urinary tract infection in girls: The cost-effectiveness of currently recommended investigative routines. Paediatr Nephrol. 1997;11:174–177
  7. Kass EJ, Kernen KM, Carey JM. Paediatric urinary tract infection and the necessity of complete urologic imaging. BJU Int. 2000;86:94–96
  8. Hoberman A, Charron M, Hickey RW, et al. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med. 2003;348:195–202
  9. Hansson S. Urinary tract infection in children: The point of view of the paediatric nephrologist. In:  Prigent A,  Piepsz A editor. Functional Imaging in Nephro-Urology. London: Taylor and Francis; 2006;p. 233–239
  10. Gordon I. Urinary tract infection in children: Introduction. In:  Prigent A,  Piepsz A editor. Functional Imaging in Nephro-Urology. London: Taylor and Francis; 2006;p. 213–215
  11. American Academy of PediatricsCommittee on Quality ImprovementSubcommittee on Urinary Tract Infection. Practice parameter: The diagnosis, treatment and evaluation of the initial urinary tract infection in febrile infants and young children. Pediatrics. 1999;103:843–852
  12. Gelfand MJ, Barr LL, Abunko O. The initial renal ultrasound examination in children with urinary tract infection: The prevalence of dilated uropathy has decreased. Pediatric Radiol. 2000;30:665–670
  13. Dacher JN. Urinary Tract Infection in children: The point of view of the radiologist. In:  Prigent A,  Piepsz A editor. Functional Imaging in Nephro-Urology. London: Taylor and Francis; 2006;p. 217–222
  14. Anderson NG, Wright S, Abbott GD. Fetal renal pelvic dilatation—poor predictor of familial vesicoureteral reflux. Pediatr Nephrol. 2003;18:902–905
  15. Nishisaki A. Imaging studies after a first febrile urinary tract infection in young children. (comment) N Engl J Med. 2003;348:1812
  16. Hitzel A, Liard A, Vera P, et al. Color and power doppler sonography versus DMSA scintigraphy in acute pyelonephritis and in prediction of renal scarring. J Nucl Med. 2002;43:27–32
  17. Hansson S, Dhamey M, Sigstrom O, et al. Dimercapto-succinic acid scintigraphy instead of voiding cystourethrography for infants with urinary tract infection. J Urol. 2004;172:1071–1074
  18. Moorthy I, Easty M, McHugh K, et al. The presence of vesicoureteric reflux does not identify a population at risk for renal scarring following a first urinary tract infection. Arch Dis Child. 2005;90:733–736
  19. Goldraich NP, Goldraich IH. Update on dimercapto-succinic acid renal scanning in children with urinary tract infection. Pediatr Nephrol. 1995;9:221–226
  20. Majd M, Nussbaum Blask AR, et al. Acute pyelonephritis: comparison of diagnosis with 99mTc-DMSA, SPECT, spiral CT, MR imaging and power Doppler US in an experimental pig model. Radiology. 2001;218:101–108
  21. Piepsz A, Blaufox MD, Gordon I, et al. Consensus on renal cortical scintigraphy in children with urinary tract infection. Semin Nucl Med. 1999;29:160–174
  22. Piepsz A, Colarinha P, Gordon I, et al. Guidelines for 99mTc-DMSA scintigraphy in children. Eur J Nucl Med. 2001;28:37–41BP
  23. Sisayan RM, Rossleigh MA, Mackey DWJ. Normograms of renal length in children obtained from DMSA scintigraphy. Clin Nucl Med. 1993;18:970–973
  24. Rushton HG, Majd M, Chandra R, et al. Evaluation of technetium–99m–dimercaptosuccinic acid renal scans in the detection and localization of experimental acute pyelonephritis in piglets. J Urol. 1988;140:1169–1174
  25. Parkhouse HG, Godley ML, Cooper J, et al. Renal imaging with 99mTc- labelled DMSA in the detection of acute pyelonephritis: an experimental study in the pig. Nucl Med Commun. 1989;10:63–70
  26. Rosenberg AR, Rossleigh MA, Brydon MP, et al. Evaluation of acute urinary tract infection in children by dimercaptosuccinic acid scintigraphy: A prospective study. J Urol. 1992;148:1746–1749
  27. Levtchenko E, Lahy C, Levy J, et al. Treatment of children with acute pyelonephritis: A prospective randomized study. Pediatr Nephrol. 2001;16:878–884
  28. Levtchenko EN, Lahy C, Levy J, et al. Role of Tc-99m DMSA scintigraphy in the diagnosis of culture negative pyelonephritis. Pediatr Nephrol. 2001;16:503–506
  29. Rossleigh MA, Farnsworth RH, Leighton DM, et al. Technetium–99m dimercaptosuccinic acid scintigraphy studies of renal cortical scarring and renal length. J Nucl Med. 1998;39:1280–1285
  30. Jodal U, Smellie JH, Lax H, et al. Ten-year results of randomized treatment of children with severe vesicoureteral reflux (Final report of the International Reflux Study in Children). Pediatr Nephrol. 2006;21:785–792
  31. Bensman A, Ulinski T. International Vesicoureteral Reflux Study: Unsolved questions remaining. (editorial) Paediatr Nephrol. 2006;21:757–758
  32. Wheeler D, Vimalachandra D, Hodson EM, et al. Antibiotics and surgery for vesicoureteric reflux: A meta-analysis of randomised controlled trials. Arch Dis Child. 2003;88:688–694
  33. Garin EH, Olavarria F, Garcia Nieto V, et al. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: A multicentre randomised, controlled study. Pediatrics. 2006;117:626–632
  34. Wald ER. Vesicoureteral reflux: The role of antibiotic prophylaxis. Pediatrics. 2006;117:919–922(editorial)
  35. Majd M, Rushton HG, Jantausch B, et al. Relationship among vesicoureteral reflux, P-fimbriated Escherichia coli, and acute pyelonephritis in children with febrile urinary tract infection. J Pediatr. 1991;119:578–585
  36. Ditchfield MR, de Campo JF, Cook DJ, et al. Vesicoureteral reflux: an accurate predictor of acute pyelonephritis in childhood urinary tract infections?. Radiology. 1994;190:413–415
  37. Farnsworth RH, Rossleigh MA, Leighton DM, et al. The detection of reflux nephropathy in infants by 99mTechnetium dimercaptosuccinic acid studies. J Urol. 1991;145:542–546
  38. Stokland E, Hellstrom M, Jacobsson B, et al. Evaluation of DMSA scintigraphy and urography in assessing both acute and permanent renal damage in children. Acta Radiol. 1998;39:447–452
  39. Gordon I, Barkovics M, Pindoria S, et al. Primary vesicouretric reflux as a predictor of renal damage in children hospitalized with urinary tract infection: A systematic review and meta-analysis. J Am Soc Nephrol. 2003;14:739–744
  40. International Reflux Study in Children (International system of radiographic grading of vesicoureteric reflux). Pediatr Radiol. 1985;15:105–109
  41. Jequier S, Jequier JC. Reliability of voiding cystourethrography to detect reflux. AJR Am J Roentgenol. 1989;153:807–810
  42. Vernon SJ, Coulthard MG, Lambert HJ, et al. New renal scarring in children who at age 3 and 4 years had had normal scans with dimercaptosuccinic acid: Follow up study. BMJ. 1997;315:905–908
  43. Oswald J, Riccabona M, Lusuardi L, et al. Voiding cystourethrography using the suprapubic versus transurethral route in infants and children: Results of a prospective pain scale orientated study. J Urol. 2002;168:2586–2589
  44. Wilkinson AG. Percutaneous direct radionuclide cystography in children: Description of technique and early experience. Pediatr Radiol. 2002;32:511–517

PII: S0001-2998(07)00027-X

doi: 10.1053/j.semnuclmed.2007.02.006

Seminars in Nuclear Medicine
Volume 37, Issue 4 , Pages 261-268 , July 2007