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Seminars in Nuclear Medicine
Volume 37, Issue 4
, Pages 303-313
, July 2007
Pediatric Dual-Energy X-ray Absorptiometry: Technique, Interpretation, and Clinical Applications
References
- . Osteoporosis: What a clinician expects to learn from a patient’s bone density examination. Radiology. 2003;228:620–628
- Importance of precision in bone density measurements. J Clin Densitom. 2001;4:105–110
- . Position Development Conference; Diagnosis of osteoporosis in men, premenopausal women, and children. J Clin Densitom. 2004;7:17–26
- . Dual energy x-ray absorptiometry (DEXA) measurements of bone density and body composition: Promise and pitfalls. J Pediatr Endocrinol Metab. 2000;13:983–988
- . New approaches for interpreting projected bone densitometry data. J Bone Miner Res. 1992;7:137–145
- . Technical considerations for fan-beam dual-energy x-ray absorptiometry body composition measurements in pediatric studies. J Parenter Enteral Nutr. 2004;28:328–333
- Evaluation of low density spine software for the assessment of bone mineral density in children. J Bone Miner Res. 1998;13:1687–1690
- Differences in estimates of change of bone accrual and body composition in children because of scan mode selection with the prodigy densitometer. J Clin Densitom. 2005;8:65–73
- Large variations occur in bone density measurements of children when using different software. Nucl Med Commun. 2005;26:483–487
- Reference values for bone mineral density in 12- to 18-year-old girls categorized by weight, race, and age. Pediatr Radiol. 2004;34:787–792
- . The correlation between dual-energy x-ray absorptiometry measures of bone density in the proximal femur and lumbar spine of children. Skeletal Radiol. 1997;26:544–547
- Lateral femoral scan: an alternative method for assessing bone mineral density in children with cerebral palsy. Pediatr Radiol. 1998;28:241–246
- Pediatric reference data for dual x-ray absorptiometric measures of normal bone density in the distal femur. AJR Am J Roentgenol. 2002;178:439–443
- Z score prediction model for assessment of bone mineral content in pediatric diseases. J Bone Miner Res. 2001;16:1658–1664
- Radiographic vertebral morphology: A diagnostic tool in pediatric osteoporosis. J Pediatr. 2005;146:395–401
- . A Practical Guide to Bone Densitometry in Children. Bath, UK: National Osteoporosis Society; 2004;
- . The Evaluation of Osteoporosis: Dual Energy X-Ray Absorptiometry in Clinical Practice. Cambridge: Martin Dunnitz; 1994;
- Accuracy of dual-energy radiographic absorptiometry of the lumbar spine: Cadaver study. Radiology. 1990;176:171–173
- Reproducibility of pediatric whole body bone and body composition measures by dual-energy x-ray absorptiometry using the GE lunar prodigy. J Clin Densitom. 2005;8:298–304
- Measurement of bone mineral content of the lumbar spine by dual energy x-ray absorptiometry in normal children: Correlations with growth parameters. J Clin Endocrinol Metab. 1990;70:1330–1333
- Spinal bone mineral density in 335 normal and obese children and adolescents: Evidence for ethnic and sex differences. J Bone Miner Res. 1991;6:507–513
- Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab. 1991;73:555–563
- Regional and total body bone mineral content, bone mineral density, and total body tissue composition in children 8-16 years of age. Calcif Tissue Int. 1993;53:7–12
- Evolution of lumbar bone mineral content during adolescence and adulthood: A longitudinal study in 395 healthy females 10-24 years of age and 206 premenopausal women. Osteoporos Int. 1999;9:476–482
- Osteoporosis Prevention, Diagnosis, and Therapy. Available at: http://consensus.nih.gov/2000/2000Osteoporosis111html.htm. Accessed March 14, 2007
- American College of Rheumatology. Practice guidelines. Available at: http://www.rheumatology.org/publications/guidelines/index.asp?aud=mem. Accessed March 14, 2007
- http://www.acr.org/s
acr/bin.asp?TrackID=&SID=1&DID=11796&CID=1206&VID=2 &DOC=File.PDF - Lumbar bone mineral content measured by dual energy x-ray absorptiometry in newborns and infants. Acta Paediatr. 1992;81:953–958
- Dual-energy x-ray absorptiometry studies of bone mineral status in newborn infants. J Bone Miner Res. 1996;11:997–1002
- . Bone mass in healthy children: Measurement with quantitative DX. Radiology. 1991;179:735–738
- Importance of lean mass in the interpretation of total body densitometry in children and adolescents. J Pediatr. 2003;143:81–88
- Discrepancies in pediatric bone mineral density reference data: potential for misdiagnosis of osteopenia. J Pediatr. 1999;135:182–188
- Pubertal maturation characteristics and the rate of bone mass development longitudinally toward menarche. J Bone Miner Res. 2001;16:774–778
- The relationship between lean body mass and bone mineral content in paediatric health and disease. Bone. 2004;35:965–972
- Spinal bone mineral density in children aged 5.00 through 11.99 years. Am J Dis Child. 1990;144:1346–1348
- Determinants of body composition measured by dual-energy x-ray absorptiometry in Dutch children and adolescents. Am J Clin Nutr. 1997;66:232–238
- Reference data for bone density and body composition measured with dual energy x-ray absorptiometry in white children and young adults. Arch Dis Child. 2002;87:341–347
- The densitometry in Canadian children 8-17 years of age. Calcif Tissue Int. 1996;59:344–351
- . Influence of weight, age and puberty on bone size and bone mineral content in healthy children and adolescents. Acta Paediatr. 1998;87:494–499
- Body composition in children and Tanner’s stages: A study with dual-energy x-ray absorptiometry. Metabolism. 1993;42:967–970
- Discrepancies in pediatric bone mineral density reference data: Potential for misdiagnosis of osteopenia. J Pediatr. 1999;135:182–188
- Bisphosphonate-induced osteopetrosis. N Engl J Med. 2003;349:457–463
- . Overdiagnosis of osteoporosis in children due to misinterpretation of dual-energy x-ray absorptiometry (DEXA). J Pediatr. 2004;144:253–257
- Whole body bone mineral content in healthy children and adolescents. Arch Dis Child. 1997;76:9–15
- . Evaluation of whole body DXA scans in children. Bone. 2005;36:S73–S74
- . Pediatric DXA technique and interpretation. Pediatr Radiol. 2007;37:21–31
- Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J Clin Endocrinol Metab. 1991;73:1332–1339
- . Bone densitometry of the spine and femur in children by dual-energy x-ray absorptiometry. Bone Miner. 1992;17:75–85
- Volumetric bone mineral density in normal subjects, aged 5-27 years. J Clin Endocrinol Metab. 1996;81:1586–1590
- Bone acquisition in healthy children and adolescents: comparisons of dual-energy x-ray absorptiometry and computed tomography measures. J Clin Endocrinol Metab. 2005;90:1925–1928
- . Bone mineralization in children and adolescents with a milk allergy. Bone Miner. 1994;27:1–12
- . risk of inadequate bone mineralizaton in diseases involving long-term suppression of dairy products. J Pediatr Gastroenterol Nutr. 2000;30:310–313
- Two-year changes in bone and body composition in young children with a history of prolonged milk avoidance. Osteoporos Int. 2005;15:1016–1023
- Bone mineral density and importance of a gluten-free diet in patients with celiac disease in childhood. Pediatrics. 2001;108:e89
- Longitudinal changes in bone metabolism and bone mineral content in children with celiac disease during consumption of a gluten-free diet. Am J Clin Nutr. 2004;79:148–154
- Bone mineral density in children with celiac disease (Effect of a Gluten-free diet). Eur J Clin Nutr. 2006;60:358–363
- Bone mineral content and density in asymptomatic children with celiac disease on a gluten-free diet. Eur J Gastroenterol Hepatol. 2001;13:419–424
- Bone mineral density and nutritional status in children with chronic inflammatory bowel disease. Gut. 1998;42:188–194
- Bone mineral assessment by dual energy x-ray absorptiometry in children with inflammatory bowel disease: Evaluation by age or bone area. J Pediatr Gastroenterol Nutr. 2004;38:276–281
- Whole body BMC in pediatric Crohn disease: Iindependent effects of altered growth, maturation, and body composition. J Bone Miner Res. 2004;19:1961–1968
- Osteoporosis in pediatric patients suffering from chronic inflammatory bowel disease with and without steroid treatment. J Pediatr Gastroenterol Nutr. 2006;43:42–51
- . Bone mineral content in infants and children with chronic cholestatic liver disease. Pediatrics. 1993;91:1151–1154
- Deficits in size-adjusted bone mass in children with Alagille Syndrome. J Pediatr Gastroenterol Nutr. 2005;40:76–82
- Long-term outcome of bone mineral density in children who underwent a successful liver transplantation. Transplantation. 2004;78:899–903
- Bone mineral content, corrected for height or bone area, measured by DXA is not reduced in children with chronic renal disease or in hypoparathyroidism. Pediatr Nephrol. 2005;20:1466–1472
- . Decreased bone mineral density in the pediatric renal transplant population. Pediatr Transplant. 2003;7:358–363
- Bone mineral density, bone metabolism and body composition of children with chronic renal failure, with and without growth hormone treatment. Clin Endocrinol. 1998;49:665–672
- Bone density and body composition in chronic renal failure: Effects of growth hormone treatment. Pediatr Nephrol. 2000;15:221–228
- Bone mineral density after renal transplantation in children. J Pediatr. 1994;125:870–875
- Weight-/height-related bone mineral density is not reduced after renal transplantation. Pediatr Nephrol. 1998;12:343–348
- The effect of long-term growth hormone (GH) treatment on bone mineral density in children with GH deficiency (Role of GH in the attainment of peak bone mass). J Clin Endocrinol Metab. 1996;81:3077–3083
- Effect of growth hormone therapy and puberty on bone and body composition in children with idiopathic short stature and growth hormone deficiency. Bone. 2005;37:642–650
- The effect of short- and long-term growth hormone treatment on bone mineral density and bone metabolism of prepubertal children with idiopathic short stature: A 3-year study. Clin Endocrinol. 2002;57:725–730
- Longitudinal changes of lumbar bone mineral density (BMD) in patients with GH deficiency after discontinuation of treatment at final height; timing and peak values for lumbar BMD. Clin Endocrinol. 2004;60:175–184
- . Effect of GH treatment on bone mass in children with GH deficiency. J Endocrinol Invest. 2005;28(10 suppl):23–27
- . Oral contraceptive use in young women is associated with lower bone mineral density than that of controls. Osteoporos Int. 2005;16:1538–1544
- Depot medroxyprogestrone acetate, oral contraceptives and bone mineral density in a cohort of adolescent girls. J Adolesc Health. 2004;35:434–441
- A prospective comparison of bone density in adolescent girls receiving depot medroxyprogesterone acetate (Depo-Provera), levonorgestrel (Norplant), or oral contraceptives. J Pediatr. 1996;129:671–676
- . Overview of the relationship between use of progestogen-only contraceptives and bone mineral density. BJOG. 2001;108:1214–1221
- Double-blinded randomized controlled trial of estrogen supplementation in adolescent girls who receive depot medroxyprogesterone acetate for contraception. Am J Obstet Gynecol. 2005;192:42–47
- Ultrasound and x-ray-based bone densitometry in patients with anorexia nervosa. Calcif Tissue Int. 2000;66:338–341
- Abnormal bone mineral accrual in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab. 2002;87:4177–4185
- Cortical and trabecular bone density and structure in anorexia nervosa. Osteoporos Int. 2005;16:783–790
- Osteoporosis in anorexia nervosa: The influence of peak bone density, bone loss, oral contraceptive use, and exercise. J Bone Miner Res. 1992;7:1467–1474
- Bone status in cystic fibrosis. Arch Dis Child. 2001;84:516–520
- Correlates of prepubertal bone mineral density in cystic fibrosis. Arch Dis Child. 2001;85:166–171
- Normal bone mineral density in cystic fibrosis. Arch Dis Child. 2001;84:363–368
- Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study. Thorax. 2004;59:149–155
- Low bone mineral density in adults with cystic fibrosis. Thorax. 1999;54:961–967
- . Bone density in children and adolescents with cystic fibrosis. J Pediatr. 1996;128:28–39
- A prospective study of change in bone mineral density over one year in adults with cystic fibrosis. Thorax. 2002;57:719–723
- Bone acquisition and loss in children and adults with cystic fibrosis: a longitudinal study. J Pediatr. 1998;133:18–27
- Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation. Am J Respir Crit Care Med. 2000;162:941–946
- Efficacy of alendronate in adults with cystic fibrosis with low bone density. Am J Respir Crit Care Med. 2004;169:77–82
- Effect of intravenous pamidronate on bone mineral density in adults with cystic fibrosis. Thorax. 2001;56:314–316
- Bone mineral density and bone metabolism of prepubertal children with asthma after long-term treatment with inhaled corticosteroids. Pediatr Pulmonol. 1997;24:379–384
- . Bone mineral density in children with asthma receiving long-term treatment with inhaled budesonide. Am J Respir Crit Care Med. 1998;157:178–183
- Inhaled corticosteroids and bone density of children with asthma. J Asthma. 2002;39:151–157
- The effects of long term use of inhaled corticosteroids on linear growth, adrenal function and bone mineral density in children. Allergol Immunopathol. 2005;33:204–209
- Effects of high-dose inhaled corticosteroids on bone metabolism in prepubertal children with asthma. Pediatr Pulmonol. 2000;29:188–193
- Bone mineral density in prepubertal asthmatics receiving corticosteroid treatment. J Paediatr Child Health. 2001;37:67–71
- Bone mineral density of the lumbar spine and proximal femur is decreased in children with sickle cell anemia. Am J Orthop. 1998;27:43–49
- Decreased bone mineral density in prepubertal children with sickle cell disease: Correlation with growth parameters, degree of siderosis and secretion of growth factors. J Trop Pediatr. 1998;44:194–198
- Bone mineral density in children with sickle cell anemia. Pediatr Blood Cancer. 2006;47:901–906
- Bone area and bone mineral content deficits in children with sickle cell disease. Pediatrics. 2005;116:943–949
- High prevalence and correlates of low bone mineral density in young adults with sickle cell disease. Am J Hematol. 2006;81:236–241
- Low bone mass in prepubertal children with thalassemia major: Insights into the pathogenesis of low bone mass in thalassemia. J Pediatr Endocrinol Metab. 2004;17:1415–1421
- Effects of thalassemia major on bone mineral density in late adolescence. J Pediatr Endocrinol Metab. 2003;16:337–342
- Reduced bone density among children with severe hemophilia. Pediatrics. 2004;114:177–181
- Association of severe haemophilia A with osteoporosis: A densitometric and biochemical study. Q J Med. 1994;87:181–186
- Reduced bone mineral density in long-term survivors of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 1998;20:234–240
- Reduced bone mineral density in young adults following cure of acute lymphoblastic leukaemia in childhood. Br J Cancer. 1999;79:1859–1863
- Bone mineral density, body composition, and height in long-term survivors of acute lymphoblastic leukemia in childhood. Med Pediatr Oncol. 2000;35:415–420
- Bone mineral density in children with acute lymphoblastic leukaemia. Eur J Cancer. 1999;35:1693–1697
- Improvement in bone mineral density and body composition in survivors of childhood acute lymphoblastic leukemia: A 1-year prospective study. Pediatrics. 2005;116:e102–e108
- Bone mineral density and bone turnover in young adult survivors of childhood acute lymphoblastic leukaemia. Eur J Endoc. 2006;154:303–309
- J Pediatr Hematol Oncol. 1998;20:241–245
- Osteopenia in young adult survivors of childhood cancer. Med Pediatr Oncol. 1999;32:272–278
- Bone mass after treatment of malignant lymphoma in childhood. Med Pediatr Oncol. 2001;37:518–524
- Cross-sectional study of bone mineral density in adult survivors of solid pediatric cancers. J Pediatr Hematol Oncol. 2005;27:248–253
- Bone mineral density and bone metabolism in children treated for bone sarcomas. Pediatr Res. 2006;59:866–871
- Osteopenia, physical activity and health-related quality of life in survivors of brain tumors treated in childhood. Pediatr Blood Cancer. 2006;46:357–362
- . Bone-mineral density in children and adolescents who have spastic cerebral palsy. J Bone Joint Surg. 1995;77-A:1671–1681
- Bone density and metabolism in children and adolescents with moderate to severe cerebral palsy. Pediatrics. 2002;110:1–10
- Bisphosphonates to treat osteopenia in children with quadriplegic cerebral palsy: a randomized, placego-controlled clinical trial. J Pediatr. 2002;141:644–651
- Pamidronate treatment and posttreatment bone density in children with spastic quadriplegic cerebral palsy. J Clin Densitom. 2006;9:167–174
- Bone mineral density in children with myelomeningocele. Pediatrics. 1998;102:E34
- Osteoporosis in adults with meningomyelocele: An unrecognized problem at rehabilitation clinics. Arch Phys Med Rehabil. 2006;87:376–382
- Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis. Arthritis Rheum. 1996;39:746–757
- Evaluation by dual x-ray absorptiometry (DXA) of bone mineral density in children with juvenile chronic arthritis. Clin Exp Rheum. 1998;16:495–501
- Frequency of osteopenia in adolescents with early-onset juvenile idiopathic arthritis. Arthritis Rheum. 2003;48:2214–2223
- Predictors of total body bone mineral density in non-corticosteroid-treated prepubertal children with juvenile rheumatoid arthritis. Arthritis Rheum. 1997;40:1967–1975
- Total-body bone mineral content in non-corticosteroid-treated postpubertal females with juvenile rheumatoid arthritis. Arthritis Rheum. 2000;43:531–540
- Bone mineral density and body composition and influencing factors in children with rheumatic diseases treated with corticosteroids. J Pediatr Endoc Metab. 2002;15:187–192
- Bone mass change during methotrexate treatment in patients with juvenile rheumatoid arthritis. Osteoporos Int. 1999;10:20–25
- Osteoporosis in juvenile systemic lupus erthematosus: a longitudinal study on the effect of steroids on bone mineral density. Rheumatol Int. 1998;18:45–49
- Bone mineral density in juvenile systemic lupus erythematosus. Braz J Med Bio Res. 2002;35:1159–1163
- . Bone mineral density and fractures in boys with Duchenne muscular dystrophy. J Pediatr Orthop. 2000;20:71
- Bone mineral density and bone metabolism in Duchenne muscular dystrophy. Osteoporos Int. 2003;14:761–767
- Alendronate in the treatment of low bone mass in steroid-treated boys with Duchenne’s muscular dystrophy. Arch Phys Med Rehab. 2005;86:284–288
- Bone mineral density in juvenile dermatomyositis. Arthritis Rheum. 2003;48:2294–2298
- Bone mineral density of Brazilian girls with juvenile dermatomyositis. Braz J Med Biol Res. 2005;38:309–313
- Bone mineral content and collagen defects in osteogenesis imperfecta. Acta Paediatr. 1999;88:1083–1088
- . Bisphosphonate treatment in osteogensis imperfecta: Which drug, for whom, for how long?. Ann Med. 2005;37:295–302
- . Pamidronate treatment in less severe forms of osteogenesis imperfecta. J Pediatr Endocrinol Metab. 2004;17:1511–1517
- Intravenous neridronate in children with osteogenesis imperfecta: A randomized controlled study. J Bone Miner Res. 2005;20:758–763
- Intravenous pamidronate in children with moderate to severe osteogenesis imperfecta: Assessment of indices of dual-energy X-ray absorptiometry and bone metabolic markers during the first year of therapy. Bone. 2004;34:539–546
- Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvement. J Bone Miner Res. 2005;20:977–986
- Height and weight development during four years of therapy with cyclical intravenous pamidronate in children and adolescents with osteogenesis imperfecta types I, III, and IV. Pediatrics. 2003;111:1030–1036
Significant portions of this article were adapted from two of the authors’ previous works: Binkovitz LA, Henwood MJ: Pediatric DXA: Technique and interpretation. Pediatr Radiol 37:21-31, 2007; and Binkovitz LA, Sparke P, Henwood MJ: Pediatric DXA: Clinical applications. Pediatr Radiol 2007 Apr 13 [Epub ahead of print]; with kind permission from Springer Science and Business Media.
PII: S0001-2998(07)00028-1
doi: 10.1053/j.semnuclmed.2007.02.007
© 2007 Elsevier Inc. All rights reserved.
« Previous
Seminars in Nuclear Medicine
Volume 37, Issue 4
, Pages 303-313
, July 2007
