Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)

Stein, Paul D.; Gottschalk, Alexander; Sostman, H. Dirk; Chenevert, Thomas L.; Fowler, Sarah E.; Goodman, Lawrence R.; Hales, Charles A.; Hull, Russell D.; Kanal, Emanuel; Leeper, Kenneth V.; Nadich, David P.; Sak, Daniel J.; Tapson, Victor F.; Wakefield, Thomas W.; Weg, John G.; Woodard, Pamela K.

doi:10.1053/j.semnuclmed.2008.06.003

« Previous Next »Seminars in Nuclear Medicine
Volume 38, Issue 6 , Pages 462-470, November 2008

Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)

Paul D. Stein, MD
- Department of Research, St. Joseph Mercy Oakland Hospital, Pontiac, MI, and Department of Medicine, Wayne State University, Detroit, MI
- Address reprint requests to Paul D. Stein, MD, St. Joseph Mercy Oakland, 44405 Woodward Ave, Pontiac, MI 48341-5023
Alexander Gottschalk, MD
- Department of Radiology, Michigan State University, East Lansing, MI
H. Dirk Sostman, MD
- Office of the Dean, Weill Cornell Medical College and Methodist Hospital, Houston, TX
Thomas L. Chenevert, PhD
- Department of Radiology, University of Michigan, Ann Arbor, MI
Sarah E. Fowler, PhD
- The Biostatistics Center, Department of Epidemiology and Biostatistics, George Washington University, Rockville, MD
Lawrence R. Goodman, MD
- Department of Radiology, Medical College of Wisconsin, Milwaukee, WI
Charles A. Hales, MD
- Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA
Russell D. Hull, MBBS, MSc
- Department of Medicine, University of Calgary, Calgary, Alberta, Canada
Emanuel Kanal, MD
- Department of Radiology, University of Pittsburgh, Pittsburgh, PA
Kenneth V. Leeper Jr, MD
- Department of Medicine, Emory University, Atlanta, GA
David P. Nadich, MD
- Department of Radiology, New York University Medical Center, New York, NY
Daniel J. Sak, DO
- Department of Medicine, St. Joseph Mercy Oakland Hospital, Pontiac, MI
Victor F. Tapson, MD
- Department of Medicine, Duke University, Durham, NC
Thomas W. Wakefield, MD
- Department of Surgery, University of Michigan, Ann Arbor, MI
John G. Weg, MD
- Department of Medicine, University of Michigan, Ann Arbor, MI
Pamela K. Woodard, MD
- Department of Radiology, Washington University, St. Louis, MO

In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography for the diagnosis of acute pulmonary embolism (PE). A composite reference standard based on usual diagnostic methods for PE is used. All images will be read by 2 blinded and study-certified central readers. Patients with no PE according to the composite reference test will be randomized to undergo gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography. This procedure will reduce the proportion of patients with negative tests at no loss in evaluation of sensitivity and specificity.

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Supported by grants from the U.S. Department of Health and Human Services, Public Health Services, National Heart, Lung, and Blood Institute, Bethesda, Maryland: HL081593, HL177150, HL077149, HL077151, HL077154, HL081594, HL077358, HL077155, and HL077153.

PII: S0001-2998(08)00080-9

doi:10.1053/j.semnuclmed.2008.06.003

« Previous Next »Seminars in Nuclear Medicine
Volume 38, Issue 6 , Pages 462-470, November 2008

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