Seminars in Nuclear Medicine
Volume 39, Issue 3 , Pages 174-185 , May 2009

Interventions Used With Cholescintigraphy for the Diagnosis of Hepatobiliary Disease

  • Harvey A. Ziessman, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Harvey A. Ziessman, MD, Division of Nuclear Medicine, Russell H. Morgan Department of Radiology and Radiologic Science, Johns Hopkins Medical Institutions, 601 N Caroline St, JHOC 3231, Baltimore, MD 21278-0817

References 

  1. Ziessman HA, Zeman RK, Akin EA. Cholescintigraphy: Correlation with other hepatobiliary imaging modalities. In:  Sandler MP,  Coleman RE,  Patton JA, et al. editor. Diagnostic Nuclear Medicine. 4. Philadelphia: Lippincott Williams & Wilkins; 2003;p. 503–529
  2. Freitas JE, Mirkes SH, Fink-Bennett DM, et al. Suspected acute cholecystitis (Comparison of hepatobiliary scintigraphy versus ultrasonography). Clin Nucl Med. 1982;8:364–367
  3. Zeman RK, Burrell MI, Cahow CE, et al. Diagnostic utility of cholescintigraphy and ultrasonography in acute cholecystitis. Am J Surg. 1981;141:446–451
  4. Ziessman HA. Acute cholecystitis, biliary obstruction, and biliary leakage. Semin Nucl Med. 2003;33:279–296
  5. Weissmann HS, Badia J, Sugarman LA, et al. Spectrum of 99mTc-IDA cholescintigraphic patterns in acute cholecystitis. Radiology. 1981;138:167–175
  6. Weissmann HS, Frank MS, Bernstein LH, et al. Rapid and accurate diagnosis of acute cholecystitis with 99m Tc-IDA cholescintigraphy. AJR Am J Roentgenol. 1979;132:523–528
  7. Weissmann HS, Sugarman LA, Freeman LM. The clinical role of technetium-99m iminodiacetic acid cholescintigraphy. In:  Freeman LM,  Weissmann HS editor. Nuclear Medicine Annual 1981. New York: Raven Press; 1981;p. 879–1049
  8. Choy D, Shi EC, McLean RG, et al. Cholescintigraphy in acute cholecystitis: use of intravenous morphine. Radiology. 1984;151:203–207
  9. Fink-Bennett , Balon H, Robbins T, et al. Morphine-augmented cholescintigraphy: Its efficacy in detecting acute cholecystitis. J Nucl Med. 1991;32:1231–1233
  10. Kistler AM, Ziessman HA, Gooch D, et al. Morphine augmented cholescintigraphy in acute cholecystitis (A satisfactory alternative to delayed imaging). Clin Nucl Med. 1991;16:404–406
  11. Fig LM, Wahl RL, Stewart RE, et al. Morphine-augmented cholescintigraphy: Its efficacy in detection of acute cholecystitis. J Nucl Med. 1991;323:1231–1233
  12. Krishnamurthy GT, Krishnamurthy S. Nuclear Hepatology. Springer-Verlag: Berlin; 2000;
  13. Holbrook RF, Jacobson FL, Pezzuti RT, et al. Biliary patency imaging after endoscopic retrograde sphincterotomy with gallbladder in situ (Clinical impact of nonvisualization). Arch Surg. 1991;126:738–741
  14. Anchong DM, Oates E. Normal gallbladder ejection fraction after morphine augmentation. Clin Nucl Med. 1999;24:837–841
  15. Krishnamurty S, Krishnamurthy GT. Effect of sequential administration of an opioid and cholecystokinin on gallbladder ejection fraction: Brief communication. J Nucl Med. 2006;47:1463–1466
  16. Ziessman HA. Cholecystokinin cholescintigraphy: Victim of its own success?. J Nucl Med. 1999;40:2038–2042
  17. Mitsukawa T, Takemura J, Nishizono F, et al. Effects of atropine, proglumide, and somatostatin analogue on bombesin-induced gallbladder contraction and CCK secretion in humans. Am J Gastroenterol. 1989;84:1371–1374
  18. Kubota K, Sugayha K, Sunagane N, et al. Cholecystokinin antagonism by benzodiazepines in the contractile response of the isolated guinea-pig gallbladder. Eur J Pharmacol. 1985;110:225–231
  19. Masui H, Wakabayashi I, Hatake K, et al. Effects of ethanol on contractile response of the gallbladder isolated from guinea pig. Eur J Pharmacol. 1993;248:103–110
  20. Clas D, Hould FS, Rosenthall L, et al. Nifedipine inhibits cholecystokinin-induced gallbladder contraction. J Surg Res. 1989;46:479–483
  21. Grimaldi C, Darcourt J, Harris AG, et al. Cholescintigraphic study of effect of somatostatin analog, octreotide, on bile secretion and gallbladder emptying in normal subjects. Dig Dis Sci. 1993;38:1718–1721
  22. Utkan NZ, Utkan T, Sariouglu Y, et al. Investigation of the mechanism of nicotine-induced relaxation in guinea pig gallbladder. J Surg Res. 2003;110:272–275
  23. Tankurt E, Yegen BC, Biren T, et al. Influence of pirenzepine on gallbladder contraction in man induced by sham feeding or an intraduodenal meal. Digestion. 1992;51:103–109
  24. Shaffer EA, Taylor PJ, Logan K, et al. The effect of a progestin on gallbladder function in young women. Am J Obstet Gynecol. 1984;148:504–507
  25. Ishikawa Y, Takahashi T, Yamamura T. Effect of apamin and theophylline on adenosine-5-triophosphonate-induced response of the guinea pig gallbladder. Digestion. 1983;27:234–238
  26. Caturelli E, Squillante MM, Fusilli S, et al. Gallbladder emptying in patients with primary achalasia. Digestion. 1992;52:152–156
  27. Brown AM, Bradshaw MJ, Richardson R, et al. Pathogenesis of the impaired gall bladder contraction of celiac disease. Gut. 1987;28:1426–1432
  28. Murray FE, McNicholas M, Stack W, et al. Impaired fatty meal-stimulated gallbladder contractility in patients with Crohn's disease. Clin Sci (Lond). 1992;83:689–693
  29. Shaw SJ, Hajnal F, Lebovitz Y, et al. Gallbladder dysfunction in diabetes mellitus. Dig Dis Sci. 1993;38:490–496
  30. Sood GK, Baijal SS, Lahoti D, et al. Abnormal gallbladder function in patients with irritable bowel syndrome. Am J Gastroenterol. 1993;88:1387–1390
  31. Braverman DZ, Herbert D, Goldstein R, et al. Postpartum restoration of pregnancy-induced cholecystoparesis and prolonged intestinal transit time. J Clin Gastroenterol. 1988;10:642–646
  32. Johna S, Shaul D, Taylor EW, et al. Laparoscopic management of gallbladder disease in children and adolescents. JSLS. 1997;1:241–245
  33. Masclee AAM, Jansen JBMJ, Cortsens FHM, et al. Reversible gallbladder dysfunction in severe pancreatic insufficiency. Gut. 1989;30:866–872
  34. Weissmann HS, Berkowitz D, Fox MS, et al. The role of technetium-99m iminodiacetic acid (IDA) cholescintigraphy in acute acalculous cholecystitis. Radiology. 1983;146:177–180
  35. Prevot N, Mariat G, Mahul P, et al. Contribution of cholescintigraphy to the early diagnosis of acute acalculous cholecystitis in intensive care unit patients. Eur J Nucl Med. 1999;26:1317–1325
  36. Lantto E, Jarvi K, Laitinen R, et al. Scintigraphy with 99m Tc-HMPAO labeled leukocytes in acute cholecystitis. Acta Radiol. 1991;32:359–362
  37. Fink-Bennett D, Clark K, Tsai D, et al. Indium-111 leukocyte imaging in acute cholecystitis. J Nucl Med. 1991;32:803–804
  38. Goldberg HI. Cholecystokinin cholecystography. Semin Roentgenol. 1976;11:175–179
  39. Dunn FH, Christensen ED, Reynolds J, et al. Cholecystokinin cholecystography (Controlled evaluation in the diagnosis and management of patients with possible acalculous gallbladder disease). JAMA. 1974;228:997–1003
  40. Smythe A, Majeed AW, Fitzhenry M, et al. A requiem for the cholecystokinin provocation test?. Gut. 1998;43:571–574
  41. Krishnamurthy GT, Bobba VR, Kingston E. Radionuclide ejection fraction: A technique for quantitative analysis of motor function of the human gallbladder. Gastroenterology. 1981;80:482–490
  42. Middleton GW, Williams JH. Diagnostic accuracy of 99mTc-HIDA with cholecystokinin and gallbladder ejection fraction in acalculous gallbladder disease. Nucl Med Commun. 2001;22:657–661
  43. Fink-Bennett D, DeRidder P, Kolozsi WZ, et al. Cholecystokinin cholescintigraphy: detection of abnormal gallbladder motor function in patients with chronic acalculous gallbladder disease. J Nucl Med. 1991;32:1695–1699
  44. Ziessman HA. Functional hepatobiliary disease: Chronic acalculous gallbladder and chronic acalculous biliary disease. Semin Nucl Med. 2006;36:119–132
  45. Yap L, Wycherley AG, Morphett AD, et al. Acalculous biliary pain: cholecystectomy alleviates symptoms in patients with abnormal cholescintigraphy. Gastroenterology. 1991;101:786–793
  46. DiBaise JK, Oleynikov D. Does gallbladder ejection fraction predict outcome after cholecystectomy for suspected chronic acalculous gallbladder dysfunction?. A systematic Review Am J Gastroenterol. 2003;98:2605–2611
  47. Delgado-Aros S, Cremonini F, Bredenoord AJ, et al. Systematic review and meta-analysis: Does gall-bladder ejection fraction on cholecystokinin cholescintigraphy predict outcome after cholecystectomy in suspected functional biliary pain. Aliment Pharmacol Ther. 2003;18:167–174
  48. Hopman WP, Jansen JB, Rosebusch G, et al. Gallbladder contraction induced by cholecystokinin: bolus injection or infusion. BMJ. 1986;292:375–376
  49. Ziessman HA, Fahey FH, Hixson DJ. Calculation of a gallbladder ejection fraction: Advantage of continuous sincalide infusion over the three-minute infusion method. J Nucl Med. 1992;33:537–541
  50. Ziessman HA, Muenz LR, Agarwal AK, et al. Normal values for sincalide cholescintigraphy: Comparison of two methods. Radiology. 2001;221:404–410
  51. Raymond F, Lepanto L, Rosenthal L, et al. Tc-99m-IDA gallbladder kinetics and response to CCK in chronic cholecystitis. Eur J Nucl Med. 1988;14:378–381
  52. Sostre S, Canto MI, Kaloo AN. Gallbladder response to a second dose of cholecystokinin during the same imaging study. Eur J Nucl Med. 1992;19:964–965
  53. Mackie CR, Baxter JN, Grime JS, et al. Gallbladder empting in normal subjects: A data base for clinical cholescintigraphy. Gut. 1987;28:137–141
  54. Xynos E, Pechlivanides G, Zoras OJ. Reproducibility of gallbladder emptying scintigraphic studies. J Nucl Med. 1994;35:835–839
  55. Bartel TB, Juweid ME, Ponto JA, et al. Corn oil emulsion: a simple cholecystagogue for diagnosis of chronic acalculous cholecystitis. J Nucl Med. 2005;46:67–74
  56. Ziessman HA, Jones DA, Muenz LR, et al. Cholecystokinin cholescintigraphy: Methodology and normal values using a lactose-free fatty-meal food supplement. J Nucl Med. 2003;44:1263–1266
  57. Catnach SM, Fairclough PD, Trembath RC, et al. Effect of oral erythromycin on gallbladder motility in normal subjects and subjects with gallstones. Gastroenterology. 1992;102:2076–2081
  58. Zeman RK, Lee C, Jaffe MH, et al. Hepatobiliary scintigraphy and sonography in early biliary obstruction. Radiology. 1984;153:793–794
  59. Kaplun L, Weissmann HS, Rosenblatt RR, et al. The early diagnosis of common bile duct obstruction using cholescintigraphy. JAMA. 1985;254(17):2431–2434
  60. Patch GG, Morton KA, Arias JM, et al. Naloxone reverses pattern of obstruction of the distal common bile duct induced by analgesic narcotics in hepatobiliary imaging. J Nucl Med. 1991;32:1270–1272
  61. Corazziari E, Cicala M, Scopinaro F, et al. Scintigraphic assessment of SO dysfunction. Gut. 2003;52:1655–1656
  62. Sostre S, Kaloo AN, Spiegler EJ, et al. A noninvasive test of sphincter of Oddi dysfunction in postcholecystectomy patients: The scintigraphic score. J Nucl Med. 1992;33:1216–1222
  63. Craig AG, Peter D, Saccone GT, Ziesing P, et al. Scintigraphy versus manometry in patients with suspected biliary sphincter of Oddi dysfunction. Gut. 2003;52:352–357
  64. Thomas PD, Turner JG, Dobbs BR, et al. Use of (99m)Tc-DISIDA biliary scanning with morphine provocation for the detection of elevated sphincter of Oddi basal pressure. Gut. 2000;46:838–841
  65. LoGuidice JA, Geenen JE, Hogan W, et al. Efficacy of the morphine-prostigmin test for evaluating patients with suspected papillary stenosis. Dig Dis Sci. 1979;24:450–455
  66. Madacsy L, Velosy B, Lonovics J, et al. Differentiation between organic stenosis and functional dyskinesia of the sphincter of Oddi with amyl nitrite-augmented quantitative hepatobiliary scintigraphy. Eur J Nucl Med. 1994;21:203–208
  67. Bertalan V, Madacsy L, Lavics L, et al. Scintigraphic sign of functional biliary obstruction is pathognomic for sphincter of Oddi dysfunction. Hepatogastroenterology. 2004;51:76–81
  68. Latshaw RF, Kadir S, Witt WS, et al. Glucagon-induced choledochal sphincter relaxation: Aid for expulsion of impacted calculi into the duodenum. AJR Am J Roentgenol. 1981;137:614–616
  69. Fullarton GM, Falconer S, Campbell A, et al. Controlled study of the effect of nicardipine and ceruletide on the sphincter of Oddi. Gut. 1992;33:550–553
  70. Worobetz LJ, Baker RJ, McCallum JA, et al. Effect of naloxone, morphine, and an enkephalin analogue on cholecystokinin octapeptide-stimulated gallbladder emptying. Am J Gastroenterol. 1982;77:509–511
  71. Tierney S, Quian Z, Burrow C, et al. Estrogen inhibits sphincter of Oddi motility. J Surg Res. 1994;57:69–73
  72. Majd M, Reba RC, Altman RP. Effect of phenobarbital on 99mTc-IDA scintigraphy in the evaluation of neonatal jaundice. Semin Nucl Med. 1981;11:194–204
  73. Gerhold JP, Klingensmith WC, Kuni CC, et al. Diagnosis of biliary atresia with radionuclide hepatobiliary imaging. Radiology. 1983;146:499–504
  74. Poddar U, Bhattacharya A, Thapa BR, et al. Ursodeoxycholic acid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice. J Nucl Med. 2004;45:1488–1492
  75. Gilmour SM, Hershkop M, Reifen R, et al. Outcome of hepatobiliary scanning in neonatal hepatitis syndrome. J Nucl Med. 1997;38:1279–1282

PII: S0001-2998(08)00138-4

doi: 10.1053/j.semnuclmed.2008.12.002

Seminars in Nuclear Medicine
Volume 39, Issue 3 , Pages 174-185 , May 2009