Seminars in Nuclear Medicine
Volume 39, Issue 5 , Pages 341-347 , September 2009

Hybrid SPECT/CT and PET/CT Imaging: The Next Step in Noninvasive Cardiac Imaging

  • Philipp A. Kaufmann, MD

      Affiliations

    • Cardiac Imaging Section, University Hospital Zurich, Zurich, Switzerland
    • The Zurich Center for Integrative Human Physiology (ZHIP), University of Zurich, Zurich, Switzerland
    • Corresponding Author InformationAddress reprint requests to Philipp A. Kaufmann, MD, Professor of Cardiac Imaging, Director Nuclear Cardiology, University Hospital Zurich, NUK C 42, Ramistr. 100, CH-8091 Zurich, Switzerland
  • ,
  • Marcelo F. Di Carli, MD

      Affiliations

    • Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
    • Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

References 

  1. Di Carli MF, Hachamovitch R. New technology for noninvasive evaluation of coronary artery disease. Circulation. 2007;115:1464–1480
  2. Berman DS, Wong ND, Gransar H, et al. Relationship between stress-induced myocardial ischemia and atherosclerosis measured by coronary calcium tomography. J Am Coll Cardiol. 2004;44:923–930
  3. Gaemperli O, Schepis T, Kalff V, et al. Validation of a new cardiac image fusion software for three-dimensional integration of myocardial perfusion SPECT and stand-alone 64-slice CT angiography. Eur J Nucl Med Mol Imaging. 2007;34:1097–1106
  4. Gaemperli O, Schepis T, Valenta I, et al. Cardiac image fusion from stand-alone SPECT and CT: Clinical experience. J Nucl Med. 2007;48:696–703
  5. Klocke FJ, Baird MG, Lorell BH, et al. ACC: /AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging—Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to revise the 1995 guidelines for the clinical use of cardiac radionuclide imaging). J Am Coll Cardiol. 2003;42:1318–1333
  6. Di Carli MF, Dorbala S, Meserve J, et al. Clinical myocardial perfusion PET/CT. J Nucl Med. 2007;48:783–793
  7. Berman DS, Kang X, Slomka PJ, et al. Underestimation of extent of ischemia by gated SPECT myocardial perfusion imaging in patients with left main coronary artery disease. J Nucl Cardiol. 2007;14:521–528
  8. Dorbala S, Vangala D, Sampson U, et al. Value of vasodilator left ventricular ejection fraction reserve in evaluating the magnitude of myocardium at risk and the extent of angiographic coronary artery disease: A 82Rb PET/CT study. J Nucl Med. 2007;48:349–358
  9. Parkash R, deKemp RA, Ruddy TD, et al. Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease. J Nucl Cardiol. 2004;11:440–449
  10. Schuijf JD, Wijns W, Jukema JW, et al. Relationship between noninvasive coronary angiography with multi-slice computed tomography and myocardial perfusion imaging. J Am Coll Cardiol. 2006;48:2508–2514
  11. Di Carli MF, Dorbala S, Curillova Z, et al. Relationship between CT coronary angiography and stress perfusion imaging in patients with suspected ischemic heart disease assessed by integrated PET-CT imaging. J Nucl Cardiol. 2007;14:799–809
  12. Shaw LJ, Iskandrian AE. Prognostic value of gated myocardial perfusion SPECT. J Nucl Cardiol. 2004;11:171–185
  13. Budoff MJ, Dowe D, Jollis JG, et al. Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: Results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol. 2008;52:1724–1732
  14. Miller JM, Dewey M, Vavere AL, et al. Coronary CT angiography using 64 detector rows: Methods and design of the multi-centre trial CORE-64. Eur Radiol. 2009;19:816–828
  15. Miller JM, Rochitte CE, Dewey M, et al. Coronary artery evaluation using 64-row multidetector computed tomography angiography (CORE-64): Results of a multicenter, international trial to assess diagnostic accuracy compared with conventional coronary angiography. Circulation. 2007;116:2630
  16. Hoffmann U, Moselewski F, Cury RC, et al. Predictive value of 16-slice multidetector spiral computed tomography to detect significant obstructive coronary artery disease in patients at high risk for coronary artery disease: Patient-versus segment-based analysis. Circulation. 2004;110:2638–2643
  17. Mollet NR, Cademartiri F, van Mieghem CA, et al. High-resolution spiral computed tomography coronary angiography in patients referred for diagnostic conventional coronary angiography. Circulation. 2005;112:2318–2323
  18. Leber AW, Becker A, Knez A, et al. Accuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system: A comparative study using intravascular ultrasound. J Am Coll Cardiol. 2006;47:672–677
  19. Raff GL, Gallagher MJ, O'Neill WW, et al. Diagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography. J Am Coll Cardiol. 2005;46:552–557
  20. Schenker MP, Dorbala S, Hong EC, et al. Interrelation of coronary calcification, myocardial ischemia, and outcomes in patients with intermediate likelihood of coronary artery disease: A combined positron emission tomography/computed tomography study. Circulation. 2008;117:1693–1700
  21. Schepis T, Gaemperli O, Koepfli P, et al. Added value of coronary artery calcium score as an adjunct to gated SPECT for the evaluation of coronary artery disease in an intermediate-risk population. J Nucl Med. 2007;48:1424–1430
  22. He ZX, Hedrick TD, Pratt CM, et al. Severity of coronary artery calcification by electron beam computed tomography predicts silent myocardial ischemia. Circulation. 2000;101:244–251
  23. Berman DS, Wong ND, Gransar H, et al. Relationship between stress-induced myocardial ischemia and atherosclerosis measured by coronary calcium tomography. J Am Coll Cardiol. 2004;44:923–930
  24. Mahmarian JJ. Computed tomography coronary angiography as an anatomic basis for risk stratification: Deja vu or something new?. J Am Coll Cardiol. 2007;50:1171–1173
  25. Husmann L, Herzog BA, Gaemperli O, et al. Diagnostic accuracy of computed tomography coronary angiography and evaluation of stress-only single-photon emission computed tomography/computed tomography hybrid imaging: Comparison of prospective electrocardiogram-triggering vs. retrospective gating. Eur Heart J. 2008;30:600–607
  26. Namdar M, Hany TF, Koepfli P, et al. Integrated PET/CT for the assessment of coronary artery disease: A feasibility study. J Nucl Med. 2005;46:930–935
  27. Rispler S, Keidar Z, Ghersin E, et al. Integrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions. J Am Coll Cardiol. 2007;49:1059–1067
  28. van Werkhoven JM, Schuijf JD, Gaemperli O, et al. Prognostic value of multislice computed tomography and gated single photon emission computed tomography in patients with suspected coronary artery disease. J Am Coll Cardiol. 2009;53:623–632
  29. Hausleiter J, Meyer T, Hadamitzky M, et al. Radiation dose estimates from cardiac multislice computed tomography in daily practice: Impact of different scanning protocols on effective dose estimates. Circulation. 2006;113:1305–1310
  30. Husmann L, Valenta I, Gaemperli O, et al. Feasibility of low-dose coronary CT angiography: First experience with prospective ECG-gating. Eur Heart J. 2008;29:191–197
  31. Husmann L, Valenta I, Kaufmann PA. Coronary angiography with low-dose computed tomography at 1.4 mSv. Herz. 2008;33:75
  32. Herzog BA, Husmann L, Burkhard N, et al. Accuracy of low-dose computed tomography coronary angiography using prospective electrocardiogram-triggering: First clinical experience. Eur Heart J. 2008;29:3037–3042
  33. Rybicki FJ, Otero HJ, Steigner ML, et al. Initial evaluation of coronary images from 320-detector row computed tomography. Int J Cardiovasc Imaging. 2008;24:535–546
  34. Herzog BA, Husmann L, Landmesser U, et al. Low-dose computed tomography coronary angiography and myocardial perfusion imaging: Cardiac hybrid imaging below 3mSv. Eur Heart J. 2009;30:644

 Supported by a grant from the Swiss National Science Foundation (to P.A.K.) (SNSF-professorship grant No. PP00A-114706).

PII: S0001-2998(09)00018-X

doi: 10.1053/j.semnuclmed.2009.03.007

Seminars in Nuclear Medicine
Volume 39, Issue 5 , Pages 341-347 , September 2009