Seminars in Nuclear Medicine
Volume 40, Issue 4 , Pages 271-282 , July 2010

Altered Biodistribution and Incidental Findings on Gallium and Labeled Leukocyte/Bone Marrow Scans

  • Charito Love, MD

      Affiliations

    • Division of Nuclear Medicine, St. Vincent Catholic Medical Center, New York, NY
    • Corresponding Author InformationAddress reprint requests to Charito Love, MD, Division of Nuclear Medicine, St. Vincent Catholic Medical Center, 170 West 12th Street, New York, NY 10011
  • ,
  • Christopher J. Palestro, MD

      Affiliations

    • Hofstra University School of Medicine in partnership with North Shore-LIJ Health System, Hempstead, NY
    • Division of Nuclear Medicine and Molecular Imaging, North Shore Long Island Jewish Health System, Manhasset and New Hyde Park, NY

References 

  1. Palestro CJ. The current role of gallium imaging in infection. Semin Nucl Med. 1994;24:128–141
  2. Nelson B, Hayes RL, Edwards CL, et al. Distribution of gallium in human tissues after intravenous administration. J Nucl Med. 1972;13:92–100
  3. Larson SM, Milder MS, Johnston GS. Interpretation of the 67Ga photoscan. J Nucl Med. 1973;14:208–214
  4. Palestro CJ, Malat J, Collica CJ, et al. Incidental diagnosis of pregnancy on bone and gallium scintigraphy. J Nucl Med. 1986;27:370–372
  5. Lopez OL, Maisano ER. Ga-67 uptake post Cesarean section. Clin Nucl Med. 1984;9:103–104
  6. Desai AG, Intenzo C, Park C, et al. Drug-induced gallium uptake in the breasts. Clin Nucl Med. 1987;12:703–704
  7. Vazquez R, Oates E, Sarno RC, et al. Gallium-67 breast uptake in a patient with hypothalamic granuloma (sarcoid). J Nucl Med. 1988;29:118–121
  8. Engelstad B, Luks S, Hattner RS. Altered 67Ga citrate distribution in patients with multiple red blood cell transfusion. AJR Am J Roentgenol. 1982;139:755–759
  9. Hattner RS, White DL. Gallium-67/stable gadolinium antagonism: MRI contrast agent markedly alters the normal biodistribution of Gallum-67. J Nucl Med. 1990;31:1844–1846
  10. Hoffer PB, Samuel A, Bushberg JT, et al. Desferoxamine mesylate (desferal): A contrast-enhancing agent for Ga-67 imaging. Radiology. 1979;131:775–779
  11. Hoffer PB, Samuel A, Bushberg JT, et al. Effect of desferoxamine on tissue and tumor retention of gallium-67: Concise communication. J Nucl Med. 1979;20:248–251
  12. Larson SM, Rasey JS, Grunaum Z, et al. Pharmacologic enhancement of gallium-67 tumor-to-blood ratios for EMT-6 sarcoma. (BALB/c mice). Radiology. 1979;130:241–244
  13. Oster ZH, Larson SM, Wagner HN. Possible enhancement of 67Ga-imaging by iron dextran. J Nucl Med. 1976;17:356–358
  14. Palestro CJ, Love C, Miller TT. Diagnostic imaging tests and microbial infections. Cell Microbiol. 2007;9:2323–2333
  15. Love C, Palestro CJ. Radionuclide imaging of infection. J Nucl Med Technol. 2004;32:47–57
  16. Love C, Opoku-Agyemang P, Tomas MB, et al. Pulmonary activity on labeled leukocyte images: Physiologic, pathologic, and imaging correlation. Radiographics. 2002;22:1385–1393
  17. Love C, Tomas MB, Palestro CJ. Pulmonary uptake on labeled leukocyte images: Uptake patterns and their significance. Nucl Med Commun. 2002;23:559–563
  18. Mercandetti M, Cohen AJ. Plastic Surgery: Wound Healing, Healing and Repair. March, emedicine, 2008, p 27:1:1-9 http://emedicine.medscape.com/article/1298129-overviewAccessed: February 3, 2010
  19. Megiovanni AM, Sanchez F, Robledo-Sarmiento M, et al. Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: A new link between leukocytes upstream of T lymphocytes. J Leukoc Biol. 2006;9:977–988
  20. Palestro CJ, Love C, Tronco GG, et al. Role of radionuclide imaging in the diagnosis of postoperative infection. Radiographics. 2000;20:1649–1660
  21. Dudiak C, Ali A, Dickerson M, et al. Acute tentorial subdural hematoma as false-positive in indium-111 leukocyte scintigraphy. Clin Nucl Med. 1985;10:513–514
  22. Vogler JB, Murphy WA. Bone marrow imaging. Radiology. 1988;168:679–693
  23. Palestro CJ, Love C, Tronco GG, et al. Combined labeled leukocyte and technetium-99m sulfur colloid marrow imaging for diagnosing musculoskeletal infection: Principles, technique, interpretation, indications and limitations. Radiographics. 2006;26:859–870
  24. Kim SC, Krynyckyi BR, Machac J, et al. Patterns of red marrow in the adult femur. Clin Nucl Med. 2006;31:739–741
  25. Miron S, Minotti A, Crass J. Accumulation of In-111 tagged white blood cells in heterotopic new bone. Clin Nucl Med. 1992;17:972–973
  26. Palestro CJ, Kim CK, Swyer AJ, et al. Total hip arthroplasty: Periprosthetic 111In labeled leukocyte activity and complementary 99mTc sulfur colloid imaging in suspected infection. J Nucl Med. 1990;31:1950–1955
  27. King AD, Peters AM, Stuttle AWJ, et al. Imaging of bone infection with labeled white blood cells: Role of contemporaneous bone marrow imaging. Eur J Nucl Med. 1990;17:148–151
  28. Seabold JE, Nepola JV, Marsh JL, et al. Postoperative bone marrow alterations: Potential pitfalls in the diagnosis of osteomyelitis with In-111-labeled leukocyte scintigraphy. Radiology. 1991;180:741–747
  29. Palestro CJ, Swyer AJ, Kim CK, et al. Infected knee prosthesis: Diagnosis with In-111-leukocyte, Tc-99m-sulfur colloid and Tc-99m-MDP imaging. Radiology. 1991;179:645–648
  30. Palestro CJ, Roumanas P, Swyer AJ, et al. Diagnosis of musculoskeletal infection using combined In-111 labeled leukocyte and Tc-99m SC marrow imaging. Clin Nucl Med. 1992;17:269–273
  31. Palestro CJ, Mehta HH, Patel M, et al. Marrow versus infection in the Charcot joint: Indium-111 leukocyte and technetium-99m sulfur colloid scintigraphy. J Nucl Med. 1998;39:346–350
  32. Love C, Marwin SE, Tomas MB, et al. Diagnosing infection in the failed joint replacement: A comparison of coincidence detection fluorine-18 FDG and indium-111-labeled leukocyte/technetium-99m-sulfur colloid marrow imaging. J Nucl Med. 2004;45:1864–1871
  33. Palestro CJ, Love C. Radionuclide imaging of musculoskeletal infection: Conventional agents. Semin Musculoskelet Radiol. 2007;11:335–352
  34. Palestro CJ, Kim CK, Swyer AJ, et al. Radionuclide diagnosis of vertebral osteomyelitis: Indium-111-leukocyte and technetium-99m-methylene diphosphonate bone scintigraphy. J Nucl Med. 1991;32:1861–1865
  35. Gemmel F, Dumarey N, Palestro CJ. Radionuclide imaging of spinal infections. Eur J Nucl Med Mol Imaging. 2006;33:1226–1237
  36. Whalen JL, Brown ML, McLeod R, et al. Limitations of indium leukocyte imaging for the diagnosis of spine infections. Spine. 1991;16:193–197
  37. Palestro CJ, Love C, Miller TT. Imaging of musculoskeletal infections. Best Practice Res Clin Rheumatol. 2006;20:1197–1218
  38. Uno K, Matsui N, Nohira K, et al. Indium-111 leukocyte imaging in patients with rheumatoid arthritis. J Nucl Med. 1986;27:339–344
  39. Palestro CJ, Vega A, Kim CK, et al. Appearance of acute gouty arthritis on indium-111 labeled leukocyte scintigraphy. J Nucl Med. 1990;31:682–687
  40. Palestro CJ, Goldsmith SJ. In-111 labeled leukocyte imaging in a case of pseudogout. Clin Nucl Med. 1992;17:366–367
  41. Oates E, Staudinger K, Gilbertson V. Significance of nodal uptake on indium 111 labeled leukocyte scans. Clin Nucl Med. 1989;14:282–285
  42. Schmidt KG, Rasmussen JW, Wedebye IM, et al. Accumulation of indium-111-labeled granulocytes in malignant tumors. J Nucl Med. 1988;29:479–484
  43. Lamki LM, Kasi LP, Haynie TP. Localization of indium-111 leukocytes in noninfected neoplasms. J Nucl Med. 1988;29:1921–1926
  44. Williamson SL, Williamson MR, Seibert JJ, et al. Indium-111 leukocyte accumulation in submandibular gland saliva as a cause for false-positive gut uptake in children. Clin Nucl Med. 1987;12:867–868
  45. Palestro CJ, Finn C. Indium-111 leukocyte imaging in Gaucher's disease. J Nucl Med. 1993;34:818–820
  46. Palestro CJ, Kim CK, Vega A, et al. Acute effect of radiation therapy on indium-111 labeled leukocyte uptake in bone marrow. J Nucl Med. 1989;30:1889–1891
  47. Mok YP, Carney WH, Fernandez-Ulloa M. Skeletal photopenic lesions in In-111 WBC imaging. J Nucl Med. 1984;25:1322–1326

PII: S0001-2998(10)00019-X

doi: 10.1053/j.semnuclmed.2010.03.004

Seminars in Nuclear Medicine
Volume 40, Issue 4 , Pages 271-282 , July 2010