Seminars in Nuclear Medicine
Volume 42, Issue 1 , Pages 11-26 , January 2012

The Bone Scan

  • Arnold I. Brenner, DO, MMM, CPE

      Affiliations

    • Staten Island University Hospital, Staten Island, NY
    • Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY
    • Corresponding Author InformationAddress reprint requests to: Arnold I. Brenner, DO, Nuclear Medicine and PET, Staten Island University Hospital, 475 Seaview Avenue, Staten Island, NY 10305
    • ,
  • June Koshy, MD

      Affiliations

    • Staten Island University Hospital, Staten Island, NY
    • ,
  • Jose Morey, MD

      Affiliations

    • Staten Island University Hospital, Staten Island, NY
    • ,
  • Cheryl Lin, MD

      Affiliations

    • Staten Island University Hospital, Staten Island, NY
    • ,
  • Jason DiPoce, MD

      Affiliations

    • Staten Island University Hospital, Staten Island, NY

References 

  1. Subramanian G, McAfee JG, Bell EG, et al. 99mTc-labeled polyphosphate as a skeletal imaging agent. Radiology. 1972;102:701–704
  2. Subramanian G, McAfee JG, Blair RJ, et al. Technetium-99m-methylene diphosphonate—a superior agent for skeletal imaging: Comparison with other technetium complexes. J Nucl Med. 1975;16:744–755
  3. Mettler FA, Bhargavan M, Thomadsen BR, et al. Nuclear medicine exposure in the United States, 2005-2007: Preliminary results. Semin Nucl Med. 2008;38:384–391
  4. Johnson RP. The role of bone imaging in orthopedic practice. Semin Nucl Med. 1997;27:386–389
  5. Harcke HT, Mandell GA. Scintigraphic evaluation of the growth plate. Semin Nucl Med. 1993;23:266–273
  6. Jones AG, Francis MD, Davis MA. Bone scanning: Radionuclidic reaction mechanisms. Semin Nucl Med. 1976;6:3–18
  7. Vijayanathan S, Butt S, Gnanasegaran G, et al. Advantages and limitations of imaging the musculoskeletal system by conventional radiological, radionuclide, and hybrid modalities. Semin Nucl Med. 2009;39:357–368
  8. In:  Ziessman H,  O'Malley JP,  Thall JH editor. ed 3. Nuclear Medicine: The Requisites. MO, Mosby: St Louis; 2006;p. 120
  9. Patel M. Upper extremity radionuclide bone imaging: Shoulder, arm, elbow, and forearm. Semin Nucl Med. 1998;28:3–13
  10. Handmaker H, Leonards R. The bone scan in inflammatory osseous disease. Semin Nucl Med. 1976;6:95–105
  11. Israel O, Sandler M. Nuclear medicine is able to detect disease-related dysfunction. Semin Nucl Med. 2009;39:234–235
  12. Hamdy RC, Babyn PS, Krajbich JI. Use of bone scan in management of patients with peripheral gangrene due to fulminant meningococcemia. J Pediatr Orthop. 1993;13:447–451
  13. Merlino DA. Nuclear medicine facility survey: SNM 2003 survey reporting on 2002 cost and utilization. J Nucl Med Technol. 2004;32:215–219
  14. Blau M, Nagler W, Bender MA. Fluorine-18: A new isotope for bone scanning. J Nucl Med. 1962;3:332–334
  15. Fernandez-Ulloa M, Klostermeier TT, Lancaster KT. Orthopaedic nuclear medicine: The pelvis and hip. Semin Nucl Med. 1998;28:25–40
  16. Freeman LM, Blaufox MD. Letter from the editors: Dedicated imaging devices. Semin Nucl Med. 2011;41:149–150
  17. Ben-Haim S, Israel O. Breast cancer: Role of SPECT and PET in imaging bone metastases. Semin Nucl Med. 2009;39:408–415
  18. Cook GJ, Houston S, Rubens R, et al. Detection of bone metastases in breast cancer by 18FDG PET: Differing metabolic activity in osteoblastic and osteolytic lesions. J Clin Oncol. 1998;16:3375–3379
  19. Schirrmeister H. Detection of bone metastases in breast cancer by positron emission tomography. Radiol Clin North Am. 2007;45:669–676
  20. Uematsu T, Yuen S, Yukisawa S, et al. Comparison of FDG PET and SPECT for detection of bone metastases in breast cancer. AJR Am J Roentgenol. 2005;184:1266–1273
  21. Chua S, Gnanasegaran G, Cook GJ. Miscellaneous cancers (lung, thyroid, renal cancer, myeloma, and neuroendocrine tumors): Role of SPECT and PET in imaging bone metastases. Semin Nucl Med. 2009;39:416–430
  22. Du Y, Cullum I, Illidge TM, et al. Fusion of metabolic function and morphology: Sequential [18F]fluorodeoxyglucose positron-emission tomography/computed tomography studies yield new insights into the natural history of bone metastases in breast cancer. J Clin Oncol. 2007;25:3440–3447
  23. Yang SN, Liang JA, Lin FJ, et al. Comparing whole body (18)F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphonate bone scan to detect bone metastases in patients with breast cancer. J Cancer Res Clin Oncol. 2002;128:325–328
  24. Delbeke D, Schöder H, Martin WH, et al. Hybrid imaging (SPECT/CT and PET/CT): Improving therapeutic decisions. Semin Nucl Med. 2009;39:308–340
  25. Basu S, Chryssikos T, Moghadam-Kia S, et al. Positron emission tomography as a diagnostic tool in infection: Present role and future possibilities. Semin Nucl Med. 2009;39:36–51
  26. Freeman LM, Blaufox MD. The radionuclide bone scan has been one of the cornerstones of nuclear medicine practice. Semin Nucl Med. 2009;39:355
  27. Chilton HM, Francis MD, Thrall JH. Radiopharmaceuticals for bone and bone marrow imaging. In:  Swanson DP,  Chilton HM,  Thrall JH editor. Pharmaceuticals in Medical Imaging: Radiopaque Contrast Media, Radiopharmaceuticals, Enhancement Agents for Magnetic Resonance Imaging and Ultrasound. New York: Macmillan; 1990;p. 537–563
  28. Grant FD, Fahey FH, Packard AB, et al. Skeletal PET with 18F-fluoride: Applying new technology to an old tracer. J Nucl Med. 2008;49:68–78
  29. Segall G, Delbeke D, Stabin MG, et al. SNM practice guideline for sodium 18F-fluoride PET/CT bone scans 1.0. J Nucl Med. 2010;51:1813–1820
  30. Vande Streek P, Carretta RF, Weiland FL, et al. Upper extremity radionuclide bone imaging: The wrist and hand. Semin Nucl Med. 1998;28:14–24
  31. Beheshti M, Langsteger W, Fogelman I. Prostate cancer: Role of SPECT and PET in imaging bone metastases. Semin Nucl Med. 2009;39:396–407
  32. O'Mara RE. Bone scanning in osseous metastatic disease. JAMA. 1974;229:1915–1917
  33. In:  Taylor A,  Schuster D,  Alazraki N editor. Clinician's Guide to Nuclear Medicine. ed 2. Reston, VA: Society of Nuclear Medicine; 2006;
  34. Corcoran RJ, Thrall JH, Kyle RW, et al. Solitary abnormalities in bone scans of patients with extraosseous malignancies. Radiology. 1976;121:663–667
  35. In:  Mettler FA,  Guiberteau MJ editor. Essentials of Nuclear Medicine Imaging. ed 5. Philadelphia, PA: W. B. Saunders; 2006;p. 251
  36. Barai S, Bandopadhayaya GP, Malhotra A, et al. Does I-131-MIBG underestimate skeletal disease burden in neuroblastoma?. Postgrad Med. 2004;50:257–261
  37. Gnanasegaran G, Barwick T, Adamson K, et al. Multislice SPECT/CT in benign and malignant bone disease: When the ordinary turns into the extraordinary. Semin Nucl Med. 2009;39:431–442
  38. Horger M, Bares R. The role of single-photon emission computed tomography/Computed tomography in benign and malignant bone disease. Semin Nucl Med. 2006;36:286–294
  39. Ryan PJ. Orthopaedic manifestations of systemic disease. Semin Nucl Med. 1998;28:124–131
  40. Fournier RS, Holder LE. Reflex sympathetic dystrophy: Diagnostic controversies. Semin Nucl Med. 1998;28:116–123
  41. Lee GW, Weeks PM. The role of bone scintigraphy in diagnosing reflex sympathetic dystrophy. J Hand Surg Am. 1995;20:458–463
  42. Holder LE, MacKinnon SE. Reflex sympathetic dystrophy in the hands: Clinical and scintigraphic criteria. Radiology. 1984;152:517–522
  43. Stumpe KD, Strobel K. Osteomyelitis and Arthritis. Semin Nucl Med. 2009;39:27–35
  44. Stumpe KD, Dazzi H, Schaffner A, et al. Infection imaging using whole-body FDG-PET. Eur J Nucl Med. 2000;27:822–832
  45. Mader JT, Shirtliff M, Calhoun JH. The host and the skeletal infection: Classification and pathogenesis of acute bacterial bone and joint sepsis. Baillieres Best Pract Res Clin Rheumatol. 1999;13:1–20
  46. Majd M, Frankel RS. Radionclide imaging in skeletal inflammatory and ischemic disease in children. AJR Am J Roentgenol. 1976;126:832–841
  47. Gilday DL, Paul DJ, Paterson J. Diagnosis of osteomyelitis in children by combined blood pool and bone imaging. Radiology. 1975;117:331–335
  48. Sullivan DC, Rosenfield NS, Ogden J, et al. Problems in the scintigraphic detection of osteomyelitis in children. Radiology. 1980;135:731–736
  49. Maurer AH, Chen DC, Camargo EE, et al. Utility of three-phase skeletal scintigraphy in suspected osteomyelitis: Concise communication. J Nucl Med. 1981;22:941–949
  50. Nadel HR. Bone scan update. Semin Nucl Med. 2007;37:334–341
  51. Mandell GA. Nuclear medicine in pediatric orthopedics. Semin Nucl Med. 1998;28:95–115
  52. Silberstein EB, Elgazzar AH, Fernandez-Ulloa M. Skeletal scintigraphy in non-neoplastic osseous disorders. In:  Henkin RE,  Boles A,  Dillehay CL, et al. editor. Nuclear Medicine. St Louis, MO: Mosby; 1996;
  53. Trueta J. The three types of acute haematogenous osteomyelitis. Bone Joint Surg. 1959;41:671–680
  54. Offiah AC. Acute osteomyelitis, septic arthritis and discitis: Differences between neonates and older children. Eur J Radiol. 2006;60:221–232
  55. Asmar BI. Osteomyelitis in the neonate. Infect Dis Clin North Am. 1992;6:117–132
  56. In:  Mettler FA,  Guiberteau MJ editor. ed 5. Essentials of Nuclear Medicine Imaging. vol 291:Philadelphia, PA: W. B. Saunders; 2006;p. 276
  57. Orzel JA, Rudd TG. Heterotopic bone formation: Clinical, laboratory, and imaging correlation. J Nucl Med. 1985;26:125–132
  58. Mochizuki T, Tauxe WN, Perper JA. Technetium-99m MDP scintigraphy of rhabdomyolysis induced by exertional heat stroke: A case report. Ann Nucl Med. 1990;4:111–113
  59. Van Riet J, Mortelmans L. Bone scintigraphy in electrocution wounds and comparison with FDG-PET images. Eur J Nucl Med Mol Imaging. 2008;35:448
  60. Chang LY, Yang JY. The role of bone scans in electric burns. Burns. 1991;17:250–253
  61. Sarmiento AH, Alba J, Lanaro AE, et al. Evaluation of soft-tissue calcifications in dermatomyositis with 99mTc-phosphate compounds: Case report. J Nucl Med. 1975;16:467–468
  62. Bar-Sever Z, Mukamel M, Harel L, et al. Scintigraphic evaluation of calcinosis in juvenile dermatomyositis with Tc-99m MDP. Clin Nucl Med. 2000;25:1013–1016
  63. Gnanasegaran G, Cook G, Adamson K, et al. Patterns, variants, artifacts, and pitfalls in conventional radionuclide bone imaging and SPECT/CT. Semin Nucl Med. 2009;39:380–395
  64. Conway JJ, Collins M, Tanz RR, et al. The role of bone scintigraphy in detecting child abuse. Semin Nucl Med. 1993;23:321–333
  65. Mandelstam SA, Cook D, Fitzgerald M, et al. Complementary use of radiological skeletal survey and bone scintigraphy in detection of bony injuries in suspected child abuse. Arch Dis Child. 2003;88:387–390
  66. Gilday DLAsh Jm, Green MD. Child abuse: Its complete evaluation by one radiopharmaceutical. J Nucl Med. 1980;29:10
  67. Ali A, Tetalman MR, Fordham EW, et al. Distribution of hypertrophic pulmonary osteoarthropathy. AJR Am J Roentgenol. 1980;134:771–780
  68. Love C, Din AS, Tomas MB, et al. Radionuclide bone imaging: An illustrative review. Radiographics. 2003;23:341–358
  69. Lausten GS, Hesse B, Thygesen V, et al. Prediction of late complications of femoral neck fractures by scintigraphy. Int Orthop. 1992;16:260–264
  70. Sutherland AD, Savage JP, Patterson DC, et al. The nuclide bone-scan in the diagnosis and management of Perthes' disease. J Bone Joint Surg Br. 1980;62-B:300–306
  71. Della Valle C, Parvizi J, Bauer TW, et al. Diagnosis of periprosthetic joint infections of the hip and knee. J Am Acad Orthop Surg. 2010;18:760–770
  72. Etchebehere EC, Etchebehere M, Gamba R, et al. Orthopedic pathology of the lower extremities: Scintigraphic evaluation in the thigh, knee, and leg. Semin Nucl Med. 1998;28:41–61
  73. Love C, Marwin SE, Palestro CJ. Nuclear medicine and the infected joint replacement. Semin Nucl Med. 2009;39:66–78
  74. Koba W, Kim K, Lipton ML, et al. Imaging devices for use in small animals. Semin Nucl Med. 2011;41:151–165
  75. Groves AM, Cheow H, Balan K, et al. 16-MDCT in the detection of occult wrist fractures: A comparison with skeletal scintigraphy. AJR Am J Roentgenol. 2005;184:1470–1474
  76. Matin P. The appearance of bone scans following fractures, including immediate and long-term studies. J Nucl Med. 1979;20:1227–1231
  77. Greenspan A, Stadalnik RC. A musculoskeletal radiologist's view of nuclear medicine. Semin Nucl Med. 1997;27:372–385
  78. Gates GF. SPECT bone scanning of the spine. Semin Nucl Med. 1998;28:78–94
  79. Bellah RD, Summerville DA, Treves ST, et al. Low-back pain in adolescent athletes: Detection of stress injury to the pars interarticularis with SPECT. Radiology. 1991;180:509–512
  80. Sty JR, Wells RG, Conway JJ. Spine pain in children. Semin Nucl Med. 1993;23:296–320
  81. Helms CA, Hattner RS, Vogler JB. Osteoid osteoma: Radionuclide diagnosis. Radiology. 1984;151:779–784
  82. Groshar D, Gorenberg M, Ben-Haim S, et al. Lower extremity scintigraphy: The foot and ankle. Semin Nucl Med. 1998;28:62–77
  83. Zwas ST, Elkanovitch R, Frank G. Interpretation and classification of bone scintigraphic findings in stress fractures. J Nucl Med. 1987;28:452–457
  84. Fredericson M, Bergman AG, Hoffman KL, et al. Tibial stress reaction in runners (Correlation of clinical symptoms and scintigraphy with a new magnetic resonance imaging grading system). Am J Sports Med. 1995;23:472–481
  85. Wilder RP, Sethi S. Overuse injuries: Tendinopathies, stress fractures, compartment syndrome, and shin splints. Clin Sports Med. 2004;23:55–81
  86. Scharf S. SPECT/CT imaging in general orthopedic practice. Semin Nucl Med. 2009;39:293–307
  87. Naddaf SY, Collier BD, Elgazzar AH, et al. Technical errors in planar bone scanning. J Nucl Med Technol. 2004;32:148–153
  88. Gelfand MJ, Parisi MT, Treves ST, et al. Pediatric radiopharmaceutical administered doses: 2010 North American consensus guidelines. J Nucl Med. 2011;52:318–322
  89. Freeman LM, Blaufox MD. Letter from the editors. Semin Nucl Med. 2008;38:30

PII: S0001-2998(11)00096-1

doi: 10.1053/j.semnuclmed.2011.07.005

Seminars in Nuclear Medicine
Volume 42, Issue 1 , Pages 11-26 , January 2012

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